23. The organic chemist decarboxylates beta-ketoacids at acidic pH values. In the mitochondria the pH is around 7. What does this mean in terms of the mechanism of beta-ketoacid acid decarboxylation of isocitrate in the enzyme active site? a. The carboxylate may still decarboxylate in the environment of the enzyme active site. b. The carboxylate maybe converted to the acid form in the environment of the enzyme active site prior to decarboxylation. c. The carboxylate may still decarboxylate in the environment of the enzyme active site due to the presence of NAD+. d. Both a & b maybe correct. 24. In the Krebs cycle isocitrate is oxidized to gxalosuccinic acid (also called alpha-ketoglutarate). What else happens in this step? a. NADH is oxidized to NAD+. b. NAD+ is reduced to NADH. c. Isocitrate decarboxylates. d. both b & c 25. Why is NAD+ a good oxidizing agent? a. It fits into the enzyme active site for isocitrate oxidation. b. The 'business end 'of NAD+ is electron rich. c. Isocitrate must be hydrated to generate NADH. d. The "business end 'of NAD+ is electron deficient. e, both a & d

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Questions 23, 24, and 25
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23. The organic chemist decarboxylates beta-ketoacids at acidic pH values. In the mitochondria the pH is
around 7. What does this mean in terms of the mechanism of beta-ketoacid acid decarboxylation of
isocitrate in the enzyme active site?
a. The carboxylate may still decarboxylate in the environment of the enzyme active site.
b. The carboxylate maybe converted to the acid form in the environment of the enzyme active site prior
to decarboxylation.
c. The carboxylate may still decarboxylate in the environment of the enzyme active site due to the
presence of NAD+.
d. Both a & b maybe correct.
24. In the Krebs cycle isocitrate is oxidized to oxalosuccinic acid (also called alpha-ketoglutarate). What
else happens in this step?
a. NADH is oxidized to NAD+.
b. NAD+ is reduced to NADH.
c. Isocitrate decarboxylates.
d. both b & c
25. Why is NAD+ a good oxidizing agent?
a. It fits into the enzyme active site for isocitrate oxidation.
b. The 'business end 'of NAD+ is electron rich.
c. Isocitrate must be hydrated to generate NADH.
d. The "business end 'of NAD+ is electron deficient.
e, both a & d
dictions: On Accessibility: Investigate
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F9
F11
F12
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Transcribed Image Text:O Search (Alt+Q) n 132 2022 - Read-Only hmdoyle107@gmail.cc Layout References Mailings Review View Help O Find v - 11 - A A Aa v A 三 T No Spacing Heading 1 P Replace Normal x, x A 2 A EE EEE- - E - Dictate Sensitivity A Select Paragraph Styles Editing Voice Sensitivity Font 23. The organic chemist decarboxylates beta-ketoacids at acidic pH values. In the mitochondria the pH is around 7. What does this mean in terms of the mechanism of beta-ketoacid acid decarboxylation of isocitrate in the enzyme active site? a. The carboxylate may still decarboxylate in the environment of the enzyme active site. b. The carboxylate maybe converted to the acid form in the environment of the enzyme active site prior to decarboxylation. c. The carboxylate may still decarboxylate in the environment of the enzyme active site due to the presence of NAD+. d. Both a & b maybe correct. 24. In the Krebs cycle isocitrate is oxidized to oxalosuccinic acid (also called alpha-ketoglutarate). What else happens in this step? a. NADH is oxidized to NAD+. b. NAD+ is reduced to NADH. c. Isocitrate decarboxylates. d. both b & c 25. Why is NAD+ a good oxidizing agent? a. It fits into the enzyme active site for isocitrate oxidation. b. The 'business end 'of NAD+ is electron rich. c. Isocitrate must be hydrated to generate NADH. d. The "business end 'of NAD+ is electron deficient. e, both a & d dictions: On Accessibility: Investigate DFocus home end prt sc F10 insert F6 F9 F11 F12 %23 %24 % & 2 3 4. 7 8. W R Y U P D
Expert Solution
Step 1

24) In the Krebs cycle isocitrate is oxidized to oxalosuccinic acid (also called alpha-ketoglutarate). 

Other than that, NAD+ is reduced to NADH in this step.

 

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