23. The organic chemist decarboxylates beta-ketoacids at acidic pH values. In the mitochondria the pH is around 7. What does this mean in terms of the mechanism of beta-ketoacid acid decarboxylation of isocitrate in the enzyme active site? a. The carboxylate may still decarboxylate in the environment of the enzyme active site. b. The carboxylate maybe converted to the acid form in the environment of the enzyme active site prior to decarboxylation. c. The carboxylate may still decarboxylate in the environment of the enzyme active site due to the presence of NAD+. d. Both a & b maybe correct. 24. In the Krebs cycle isocitrate is oxidized to gxalosuccinic acid (also called alpha-ketoglutarate). What else happens in this step? a. NADH is oxidized to NAD+. b. NAD+ is reduced to NADH. c. Isocitrate decarboxylates. d. both b & c 25. Why is NAD+ a good oxidizing agent? a. It fits into the enzyme active site for isocitrate oxidation. b. The 'business end 'of NAD+ is electron rich. c. Isocitrate must be hydrated to generate NADH. d. The "business end 'of NAD+ is electron deficient. e, both a & d
Neutral Amino Acids
Amino acids which do not have any charge on them are neutral amino acids.
Globular Protein
The globular proteins refer to the shape of protein specifically spherical in nature apart from spherical form fibrous, disordered and membrane-bound proteins exist. These globular proteins are miscible in water and form a colloidal solution rather than other types which might not exhibit solubility. Many classes of the fold are found in globular proteins, which render them a sphere shape. Globular fold containing proteins usually are referred to by the term globin.
Dimer
Dimers are basic organic compounds, which are derivates of oligomers. It is formed by the combination of two monomers which could potentially be strong or weak and in most cases covalent or intermolecular in nature. Identical monomers are called homodimer, the non-identical dimers are called heterodimer. The method by which dimers are formed is known as “dimerization”.
Dipeptide
A dipeptide is considered a mixture of two distinct amino acids. Since the amino acids are distinct, based on their composition, two dipeptide's isomers can be produced. Various dipeptides are biologically essential and are therefore crucial to industry.
24) In the Krebs cycle isocitrate is oxidized to oxalosuccinic acid (also called alpha-ketoglutarate).
Other than that, NAD+ is reduced to NADH in this step.
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