23.20 is what needs answerd the other is just info for it please use calculator method to answer ti83 or 84 3.20 Effects of an appetite suppressant, continue23.18 describes a study to determine if subjects withexisting cardiovascular symptoms were at an increasedrisk of cardiovascular events while taking sibutramine.Do the data give good reason to think that there is a dif-ference between the proportions of treatment and pla-cebo subjects who experienced the primary outcome?(Note that sibutramine has not been available in theUnited States since the end of 2010 due to its manu-pre-facturer's concerns over increased risk of heart attackor stroke, although at the present time, it can still bepurchased in other countries.)(a) State hypotheses, find the test statistic, and useeither software or the bottom row of Table C for theP-value. Be sure to state your conclusion.(b) Explain simply why it was important to have aplacebo group in this study. , onedence(c) is reasonablyinference are met.(a) bo(b) po = 0.368 and ,,%3Dval for the difference between the proportion of ratsthat succeed when given M and the prop on shatsucceed without it ismplesde pooled sample proportion of respondents who ateon all seven days before the survey is||23.16 (Optional topic) The plus four 90% confidence inrex23.11(b) = 0.368.(c) p = 0.396.%3D(a) § = 0.338.(a) 0.455 0.312.ent.the(b) 0.417 0.304.ers(c) 0.417 0.185.daily is(c) z = 4.94.ple(b) 3.78.on(a) 2.45.HAPTER 23 EXERCISESTen asingche langesample methods of this chapter, be sure to check thattothe drug. The study included 9804 overweight or obesesubjects with preexisting cardiovascular disease and/ortype 2 diabetes. The subjects were randomly assigned tosibutramine (4906 subjects) or a placebo (4898 subjects)in a double-blind fashion. The primary outcome mea-sured was the occurrence of any of the following events:nonfatal myocardial infarction or stroke, resuscitationafter cardiac arrest, or cardiovascular death. The primaryoutcome was observed in 561 subjects in the sibutra-mine group and 490 subjects in the placebo group."(a) Find the proportion of subjects experiencing theprimary outcome for both the sibutramine andplacebo groups.tedinas for their use are met ana to state youT conclusions in context7 Truthfulness in online profiles. Many teens have postedprofileson a social-networking website. A sample surveyn 2007 asked a random sample of teens with onlinerofiles if they included false information in their pro-files. Of 170 younger teens (aged 12 to 14), 117 saidOf 317 older teens (aged 15 to 17), 152 said yes."yes.17(a) Do these samples satisfy the guidelines for the large-sample confidence interval?6 Give a 95% confidence interval for the differencebetween the proportions of younger and older teenswho include false information in their online profiles.18 Effects of an appetite suppressant. Subjects with pre-sting cardiovascular symptoms who were receivingstoutramine, an appetite suppressant, were found to bea increased risk of cardiovascular events while taking(b) Can we safely use the large-sample confidence inter-val for comparing the proportions of sibutramineand placebo subjects who experienced the primaryoutcome! Explain.

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Lets represents the proportion of treatment group as p1 and placebo group as p2. So to test whether there is difference between the proportion of both the groups, the null hypothesis will assume or claim that the proportions are same and in against to this the alternate hypothesis will claim that the proportions are not equal. H0:p1=p2H1:p1≠p2 To conduct this test using calculator, follow the below steps: First press STAT and then choose Tests. Then select 2-propztest which mean 2 sample proportion z test. Now enter the number of success and total number of people in treatment group that is x1=561, n1=4906. Similarly enter for placebo group: x2=490, n2=4898 Then select two tailed test p1≠p2 and then select calculate. This gives the z statistic and p value.In the following steps, the procedure using hand calculation is shown. Now in treatment group there are total 561 out of 4906 are observed with primary outcomes. So the sample proportion for treatment group will be the ratio of 561 to 4906. p^1=5614906≈0.1143 Similarly, in placebo group the sample proportion will be ratio of 490 to 4898. p^2=4904898≈0.10Now compute the estimated pooled population proportion by taking the ratio of sum of the people with primary outcome of both the group to the sum of sample size of both the groups. p^=x1+x2n1+n2=561+4904906+4898=10519804≈0.107Using this pooled proportion and sample sizes of both groups, compute the standard error. SE=p^1-p^1n1+1n2=0.1071-0.10714906+14898=0.107×0.8930.000203+0.000204=0.096×0.00041≈0.006Using the standard error ans sample proportion, compute the z statistic. z=p^1-p^2SE=0.1143-0.100.006=0.01430.006≈2.38 Now using the z distribution table, the p value corresponding to 2.38 will be 0.0087 which is for one tail. The test is conducted for two-tailed, thus the p value will be: 2×0.0087=0.0174 The most common significance level is considered 0.05. So using 0.05 significance it can be observed that the p value is smaller than 0.05, thus the null hypothesis can be rejected and so the proportions are not equal for both the groups.Placebo is the group which do not use the drug for which the experiment is being conducted. If it is required to test whether a drug is effective or not then it is necessary to have a group that can be compared with the group which uses the drug. Otherwise it is not possible to conclude that the drug is effective or not.

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20 Effects of an appetite suppressant, continue 23.18 describes a study to determine if subjects with existing cardiovascular symptoms were at an increased risk of cardiovascular events while taking sibutramine. Do the data give good reason to think that there is a dif- ference between the proportions of treatment and pla- cebo subjects who experienced the primary outcome? (Note that sibutramine has not been available in the United States since the end of 2010 due to its manu- pre- facturer's concerns over increased risk of heart attack or stroke, although at the present time, it can still be purchased in other countries.) (a) State hypotheses, find the test statistic, and use either software or the bottom row of Table C for the P-value. Be sure to state your conclusion. (b) Explain simply why it was important to have a placebo group in this study.

20 Effects of an appetite suppressant, continue 23.18 describes a study to determine if subjects with existing cardiovascular symptoms were at an increased risk of cardiovascular events while taking sibutramine. Do the data give good reason to think that there is a dif- ference between the proportions of treatment and pla- cebo subjects who experienced the primary outcome? (Note that sibutramine has not been available in the United States since the end of 2010 due to its manu- pre- facturer's concerns over increased risk of heart attack or stroke, although at the present time, it can still be purchased in other countries.) (a) State hypotheses, find the test statistic, and use either software or the bottom row of Table C for the P-value. Be sure to state your conclusion. (b) Explain simply why it was important to have a placebo group in this study.

A First Course in Probability (10th Edition)

10th Edition

ISBN:9780134753119

Author:Sheldon Ross

Publisher:Sheldon Ross

Chapter1: Combinatorial Analysis

Section: Chapter Questions

Problem 1.1P: a. How many different 7-place license plates are possible if the first 2 places are for letters and...

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23.20 is what needs answerd the other is just info for it please use calculator method to answer ti83 or 84

3.20 Effects of an appetite suppressant, continue
23.18 describes a study to determine if subjects with
existing cardiovascular symptoms were at an increased
risk of cardiovascular events while taking sibutramine.
Do the data give good reason to think that there is a dif-
ference between the proportions of treatment and pla-
cebo subjects who experienced the primary outcome?
(Note that sibutramine has not been available in the
United States since the end of 2010 due to its manu-
pre-
facturer's concerns over increased risk of heart attack
or stroke, although at the present time, it can still be
purchased in other countries.)
(a) State hypotheses, find the test statistic, and use
either software or the bottom row of Table C for the
P-value. Be sure to state your conclusion.
(b) Explain simply why it was important to have a
placebo group in this study.

, one
dence
(c) is reasonably
inference are met.
(a) bo
(b) po = 0.368 and ,,
%3D
val for the difference between the proportion of rats
that succeed when given M and the prop on shat
succeed without it is
mples
de pooled sample proportion of respondents who ate
on all seven days before the survey is
||
23.16 (Optional topic) The plus four 90% confidence inrex
23.11
(b) = 0.368.
(c) p = 0.396.
%3D
(a) § = 0.338.
(a) 0.455 0.312.
ent.
the
(b) 0.417 0.304.
ers
(c) 0.417 0.185.
daily is
(c) z = 4.94.
ple
(b) 3.78.
on
(a) 2.45.
HAPTER 23 EXERCISES
Ten asing
che langesample methods of this chapter, be sure to check that
to
the drug. The study included 9804 overweight or obese
subjects with preexisting cardiovascular disease and/or
type 2 diabetes. The subjects were randomly assigned to
sibutramine (4906 subjects) or a placebo (4898 subjects)
in a double-blind fashion. The primary outcome mea-
sured was the occurrence of any of the following events:
nonfatal myocardial infarction or stroke, resuscitation
after cardiac arrest, or cardiovascular death. The primary
outcome was observed in 561 subjects in the sibutra-
mine group and 490 subjects in the placebo group."
(a) Find the proportion of subjects experiencing the
primary outcome for both the sibutramine and
placebo groups.
te
dinas for their use are met ana to state youT conclusions in context
7 Truthfulness in online profiles. Many teens have posted
profiles
on a social-networking website. A sample survey
n 2007 asked a random sample of teens with online
rofiles if they included false information in their pro-
files. Of 170 younger teens (aged 12 to 14), 117 said
Of 317 older teens (aged 15 to 17), 152 said yes."
yes.
17
(a) Do these samples satisfy the guidelines for the large-
sample confidence interval?
6 Give a 95% confidence interval for the difference
between the proportions of younger and older teens
who include false information in their online profiles.
18 Effects of an appetite suppressant. Subjects with pre-
sting cardiovascular symptoms who were receiving
stoutramine, an appetite suppressant, were found to be
a increased risk of cardiovascular events while taking
(b) Can we safely use the large-sample confidence inter-
val for comparing the proportions of sibutramine
and placebo subjects who experienced the primary
outcome! Explain.

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