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2.44 What product is formed when each compound is treated with NaH? Each of these acid-base reactions was a step in a synthesis of a commercially available drug. a. b. C. H2N OH

2.44 What product is formed when each compound is treated with NaH? Each of these acid-base reactions was a step in a synthesis of a commercially available drug. a. b. C. H2N OH

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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## Problem 2.44 **Question:** What product is formed when each compound is treated with NaH? Each of these acid-base reactions was a step in the synthesis of a commercially available drug. **Compounds:** a. The first compound is a structure with a pyrrole ring attached to a carbon chain which includes an OH group and an N,N-dimethylamino group. b. The second compound comprises an amide group attached to a methylene chain, which connects to a methyl group and a benzamide structure. c. The third compound is a 2-aminothiazole derivative with an acetyl side chain. **Explanation:** This problem involves predicting the products of acid-base reactions when each given compound is treated with sodium hydride (NaH). NaH acts as a strong base, capable of deprotonating acidic protons such as hydroxyl groups, amine groups, or other active hydrogen atoms in these structures. Each reaction represents a step in the synthesis of a drug, illustrating the real-world application of these chemical transformations.
Transcribed Image Text:## Problem 2.44 **Question:** What product is formed when each compound is treated with NaH? Each of these acid-base reactions was a step in the synthesis of a commercially available drug. **Compounds:** a. The first compound is a structure with a pyrrole ring attached to a carbon chain which includes an OH group and an N,N-dimethylamino group. b. The second compound comprises an amide group attached to a methylene chain, which connects to a methyl group and a benzamide structure. c. The third compound is a 2-aminothiazole derivative with an acetyl side chain. **Explanation:** This problem involves predicting the products of acid-base reactions when each given compound is treated with sodium hydride (NaH). NaH acts as a strong base, capable of deprotonating acidic protons such as hydroxyl groups, amine groups, or other active hydrogen atoms in these structures. Each reaction represents a step in the synthesis of a drug, illustrating the real-world application of these chemical transformations.
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