2. THP (tetrahydropyranyl) is a commonly used protecting group for alcohols. As shown below, 3,4-dihydropyran reacts with alcohol under acidic condition to afford THP ether 2A, thereby protecting the hydroxyl group. (i) Propose a mechanism for the protection reaction; (ii) Explain why compound 2B is NOT formed. ..and it is an electrophilic addition of C=C LOR acid in CH2CI2 . ... + ROH OR

2. THP (tetrahydropyranyl) is a commonly used protecting group for alcohols. As shown below, 3,4-dihydropyran reacts with alcohol under acidic condition to afford THP ether 2A, thereby protecting the hydroxyl group. (i) Propose a mechanism for the protection reaction; (ii) Explain why compound 2B is NOT formed. ..and it is an electrophilic addition of C=C LOR acid in CH2CI2 . ... + ROH OR

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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