2. THP (tetrahydropyranyl) is a commonly used protecting group for alcohols. As shown below, 3,4-dihydropyran reacts with alcohol under acidic condition to afford THP ether 2A, thereby protecting the hydroxyl group. (i) Propose a mechanism for the protection reaction; (ii) Explain why compound 2B is NOT formed. ..and it is an electrophilic addition of C=C LOR acid in CH2CI2 . ... + ROH OR

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Chapter1: Chemical Foundations
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• . .. : . . ·· · · · · : . . · · . . · ! : . . · · ·
2. THP (tetrahydropyranyl) is a commonly used protecting group for alcohols. As
shown below, 3,4-dihydropyran reacts with alcohol under acidic condition to afford a
THP ether 2A, thereby protecting the hydroxyl group.
(i) Propose a mechanism for the protection reaction;
(ii) Explain why compound 2B is NOT formed.
.and it is an electrophilic
addition of C=C
acid in CH2CI2
+
ROH
OR
it looks that ROH
is the nucleophile
..and we have
acid here
2A
2B, NOT formed
Transcribed Image Text:• . .. : . . ·· · · · · : . . · · . . · ! : . . · · · 2. THP (tetrahydropyranyl) is a commonly used protecting group for alcohols. As shown below, 3,4-dihydropyran reacts with alcohol under acidic condition to afford a THP ether 2A, thereby protecting the hydroxyl group. (i) Propose a mechanism for the protection reaction; (ii) Explain why compound 2B is NOT formed. .and it is an electrophilic addition of C=C acid in CH2CI2 + ROH OR it looks that ROH is the nucleophile ..and we have acid here 2A 2B, NOT formed
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