2. The structure below is called Jardiance, and is used to treat type Il diabetes. It is currently the 6th-best selling drug in the world with annual revenues of $6 billion. Label each chiral center in Jardiance with a star. Assign each labelled center as R or S. How many other stereoisomers of Jardiance are possible? Finally, draw and label an enantiomer and a diastereomer of Jardiance. CI HO HO OH "OH

2. The structure below is called Jardiance, and is used to treat type Il diabetes. It is currently the 6th-best selling drug in the world with annual revenues of $6 billion. Label each chiral center in Jardiance with a star. Assign each labelled center as R or S. How many other stereoisomers of Jardiance are possible? Finally, draw and label an enantiomer and a diastereomer of Jardiance. CI HO HO OH "OH

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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identify configuration of each chiral center number according to prioritization
'. How many chirality center/s are in the molecule shown below? Show them Br H3C-CH,CH(CH3)CHCH3
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2. Mark any chirality centers (asymmetric carbons) with a *. How many stereoisomers are possible? Br
Q2/ Explain the following: Cis CSH3BR2 isomer be optically inactive compound but trans CSH3BR2 isomer be optically active compound. رامانطج Q3/ Draw examples of the following a ) How many chirality centers dose ribose have ? identify b) How many stereoisomers of deoxyribose. ンンル tie c) Draw the structure of the epimer of manose with any compound.
C. Smelling Chirality. Carvone Olfactory receptors in our noses, used for the detection of odors, are chiral. Therefore, in some cases, we can tell the difference between enantiomers by their odor. Carvone is one such compound that we can distinguish between the R and S enantiomer by their odor. 1. Identify the chiral center in carvone and draw the R and S enantiomers in the indicated boxes. 2. Smell both of the enantiomers of carvone and provide a brief description of their odors in the same boxes. Carvone is perfectly safe to smell as both enantiomers are found in various foods. R-carvone S-carvone
6. Each of the following pairs of compounds contains one chirality center. Determine whether they are the same compound or enantiomers. If they are superimposable, they are the same. If they are nonsuperimposable, they are mirror images, they are enantiomers. Br C1 I_CC1 I— H Ме- Me-C Br Et H Br Cl H C-I Me-C Et Br H I-C Br Me BrC-I H H Et-C Br Me Me H H-C Br Me Et 1 2 Sk 954~ Rost 45 r Si
Where are the stereocenters in this chair conformation? What is the difference between stereocenters and chiral centers?
Q1: For each of the compounds described by the following names 1. draw a three-dimensional representation. 2. star (") each chiral center. 3. draw any planes of symmetry. 4. draw any enantiomer. S. draw any diastereomers. 6. label eachk structure vou have drawn as chiral or achiral. (a) (S)-2-chlorobutane (c) (2R,35)-2,3-dibromohexane (e) meso-hexane-3,4-diol, CH,CH,CH(OH)CH(OH)CH,CH (b) (R)-1,1,2-trimethylcyclohexane (d) (IR,2R)-1,2-dibromocyclohexane
3. Label any stereocenters in the following molecule as (R) or (S): CI