2. ne structure below and complete the Fishe 3. A :3

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**Title: Configuring Chiral Centers and Fischer Projections in Organic Chemistry**

**Objective:**
Understand the process of assigning R/S configuration to chiral centers and constructing Fischer projections from given molecular structures.

**Content:**

The image details the steps necessary to convert a three-dimensional representation of a molecule with chiral centers into its Fischer projection. The molecule contains the following substituents: 

- \( \text{CO}_2\text{H} \)
- \(\text{Br}\)
- Phenyl group (Ph)
- Hydrogen (H)

**Explanation and Steps:**

1. **Molecule Representation:**
   - The molecule is presented in a three-dimensional form with specific substituents on a chiral center.
   
2. **Rotation and Viewing:**
   - The molecule is rotated to align substituents appropriately for conversion to a Fischer projection. This involves manipulating the molecule so that substituents are visualized as horizontal and vertical lines.

3. **Assignments:**
   - Priorities based on Cahn-Ingold-Prelog rules are assigned to substituents. Typically, higher priority is given to groups with greater atomic number.
  
4. **Fischer Projection Construction:**
   - A Fischer projection is constructed where the chiral center is represented as a cross.
   - Assignments and priorities are adjusted to ensure the vertical line(backbone) is drawn with substituents in the correct priority, with side groups represented horizontally.

5. **Configuration (R/S) Assignment:**
   - After priorities are assigned, the configuration at the chiral center is determined.
   - If, when moving from highest to lowest priority around the center, the direction is clockwise, the configuration is R (from Latin rectus, right).
   - If counterclockwise, the configuration is S (from Latin sinister, left).

**Quiz:**
- Attempt to assign configurations to other chiral molecules and practice drawing Fisher projections to strengthen your understanding.

**Conclusion:**
Practicing these steps equips learners with the ability to interpret molecular structures, assign configurations, and translate three-dimensional configurations into two-dimensional representations, a crucial skill in stereochemistry and organic chemistry.
Transcribed Image Text:**Title: Configuring Chiral Centers and Fischer Projections in Organic Chemistry** **Objective:** Understand the process of assigning R/S configuration to chiral centers and constructing Fischer projections from given molecular structures. **Content:** The image details the steps necessary to convert a three-dimensional representation of a molecule with chiral centers into its Fischer projection. The molecule contains the following substituents: - \( \text{CO}_2\text{H} \) - \(\text{Br}\) - Phenyl group (Ph) - Hydrogen (H) **Explanation and Steps:** 1. **Molecule Representation:** - The molecule is presented in a three-dimensional form with specific substituents on a chiral center. 2. **Rotation and Viewing:** - The molecule is rotated to align substituents appropriately for conversion to a Fischer projection. This involves manipulating the molecule so that substituents are visualized as horizontal and vertical lines. 3. **Assignments:** - Priorities based on Cahn-Ingold-Prelog rules are assigned to substituents. Typically, higher priority is given to groups with greater atomic number. 4. **Fischer Projection Construction:** - A Fischer projection is constructed where the chiral center is represented as a cross. - Assignments and priorities are adjusted to ensure the vertical line(backbone) is drawn with substituents in the correct priority, with side groups represented horizontally. 5. **Configuration (R/S) Assignment:** - After priorities are assigned, the configuration at the chiral center is determined. - If, when moving from highest to lowest priority around the center, the direction is clockwise, the configuration is R (from Latin rectus, right). - If counterclockwise, the configuration is S (from Latin sinister, left). **Quiz:** - Attempt to assign configurations to other chiral molecules and practice drawing Fisher projections to strengthen your understanding. **Conclusion:** Practicing these steps equips learners with the ability to interpret molecular structures, assign configurations, and translate three-dimensional configurations into two-dimensional representations, a crucial skill in stereochemistry and organic chemistry.
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