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2. Another bodily process is the urea cycle. However, a carbamoyl phosphate is necessary to begin the urea cycle, which is made from the reaction of a bicarbonate ion with ATP.¹ Using what you have learned, fill in the mechanistic steps between the structures. OH Saceus TYPO th O... 2 Mg ATP NH₂ Kl Adenosine XI OH Carboxyphosphate : NH₂ +=XX² Adenosine Q. O ADP G :phosphate ADP NH QH i H₂N carbamoyl phosphate POZ ADP

2. Another bodily process is the urea cycle. However, a carbamoyl phosphate is necessary to begin the urea cycle, which is made from the reaction of a bicarbonate ion with ATP.¹ Using what you have learned, fill in the mechanistic steps between the structures. OH Saceus TYPO th O... 2 Mg ATP NH₂ Kl Adenosine XI OH Carboxyphosphate : NH₂ +=XX² Adenosine Q. O ADP G :phosphate ADP NH QH i H₂N carbamoyl phosphate POZ ADP

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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**Urea Cycle and Carbamoyl Phosphate Formation Overview** In the context of the urea cycle, the formation of carbamoyl phosphate is an essential step. This is accomplished through the reaction of a bicarbonate ion with ATP. Below is a detailed breakdown of the mechanistic steps between the structures: 1. **Bicarbonate Ion Reaction with ATP:** - **Reactants:** Bicarbonate ion, ATP, and magnesium ion (Mg²⁺). - **Process:** The bicarbonate ion reacts with ATP in the presence of Mg²⁺ to form carboxyphosphate. - **Graphical Representation:** The bicarbonate ion, with the structure of CO₃²⁻, is depicted reacting with ATP (showing the phosphate groups and adenosine) to form an intermediate complex. 2. **Formation of Carboxyphosphate:** - **Intermediate Product:** Carboxyphosphate. - **Transformation:** The ATP is transformed, releasing adenosine and converting into ADP. - **Graphical Representation:** Shows the formation of the carboxyphosphate structure, with a notable addition of a phosphate group to the bicarbonate ion. 3. **Ammonia Reaction:** - **Ammonia Addition:** NH₃ is introduced to the carboxyphosphate. - **Bond Formation:** Ammonia attacks the carboxyphosphate, leading to the formation of carbamate and inorganic phosphate release. - **Graphical Representation:** The structure shifts, illustrating ammonia's incorporation into the molecule, and freeing a phosphate group. 4. **Carbamoyl Phosphate Formation:** - **Final Product:** Carbamoyl phosphate. - **Completion:** The addition of another ATP (converted to ADP) finalizes the formation of carbamoyl phosphate. - **Graphical Representation:** Highlights the complete structure of carbamoyl phosphate, with a phosphate group attached, emphasizing its readiness to partake in the urea cycle. This detailed sequence illustrates the crucial precursor step to the urea cycle, providing foundational understanding necessary for advancing in biochemical studies.
Transcribed Image Text:**Urea Cycle and Carbamoyl Phosphate Formation Overview** In the context of the urea cycle, the formation of carbamoyl phosphate is an essential step. This is accomplished through the reaction of a bicarbonate ion with ATP. Below is a detailed breakdown of the mechanistic steps between the structures: 1. **Bicarbonate Ion Reaction with ATP:** - **Reactants:** Bicarbonate ion, ATP, and magnesium ion (Mg²⁺). - **Process:** The bicarbonate ion reacts with ATP in the presence of Mg²⁺ to form carboxyphosphate. - **Graphical Representation:** The bicarbonate ion, with the structure of CO₃²⁻, is depicted reacting with ATP (showing the phosphate groups and adenosine) to form an intermediate complex. 2. **Formation of Carboxyphosphate:** - **Intermediate Product:** Carboxyphosphate. - **Transformation:** The ATP is transformed, releasing adenosine and converting into ADP. - **Graphical Representation:** Shows the formation of the carboxyphosphate structure, with a notable addition of a phosphate group to the bicarbonate ion. 3. **Ammonia Reaction:** - **Ammonia Addition:** NH₃ is introduced to the carboxyphosphate. - **Bond Formation:** Ammonia attacks the carboxyphosphate, leading to the formation of carbamate and inorganic phosphate release. - **Graphical Representation:** The structure shifts, illustrating ammonia's incorporation into the molecule, and freeing a phosphate group. 4. **Carbamoyl Phosphate Formation:** - **Final Product:** Carbamoyl phosphate. - **Completion:** The addition of another ATP (converted to ADP) finalizes the formation of carbamoyl phosphate. - **Graphical Representation:** Highlights the complete structure of carbamoyl phosphate, with a phosphate group attached, emphasizing its readiness to partake in the urea cycle. This detailed sequence illustrates the crucial precursor step to the urea cycle, providing foundational understanding necessary for advancing in biochemical studies.
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