2. a-pinene is one of the constituents of turpentine. It can be found in many essential oils, such as that of rosemary, eucalyptus oil, and orange peels. Another common place to find a-pinene is cannabis plants. The concentration in marijuana is believed to contribute significantly to the side effects felt (such as memory impairment). H+ Propose a facile synthesis route for one of the diastereomers HBr Br2 CCl4 Br2 H₂O NaOEt EtOH LOH O3, -78°C (CH3)2S H2SO4 A

N-Nitrosamines by themselves are not significant carcinogens. However, they are activated in the liver by a class of iron-containing enzymes (members of the cytochrome P-450 family). Activation involves the oxidation of a C-H bond next to the amine nitrogen to a C-OH group. OH ОН N=0 N=O Og 'N- H+ H N,+ cyt P-450 N-Nitroso- 2-Нydroxy-N- nitrosopiperidine An alkyl diazonium ion piperidine (a carcinogen) Show how this hydroxylation product can be transformed into an alkyl diazonium ion, an active alkylating agent and therefore a carcinogen, in the presence of an acid catalyst.

Methamphetamine can exist in two possible forms, shown below: Mr. Mema is trying to convert structure A into structure B, but he forgot what Mr. Eme told him to do. Which of the reagents below can Mema add to A to get the desired B? * A B O H2 O NAOH HCI Nacl ェZエ

Explain the reaction and what product will be formed and why? ว ง (1) LDA (2) CCH₂Ph