A 74-year-old man presents to the hospital after falling down a flight of stairs. EMS found him on the ground moaning with left-sided weakness but able to answer questions. On arrival to the emergency department he remained neurologically stable. A head CT demonstrated a 5 mm right holohemispheric subdural hemorrhage. Neurosurgery was consulted and recommended initiation of an antiepileptic drug (AED). Valproic acid was started. Which of the following are concerns related to the use of valproic acid? A. It has the same early seizure prevention as phenytoin but it associates with improved mortality rate B. It is an inducer of the CYP system with multiple drug interactions C. It can result in acute renal injury and possible renal failure D. It can result in a coagulopathy which potentially could increase th. size of the patient's subdural hemorrhage.
A 74-year-old man presents to the hospital after falling down a flight of stairs. EMS found him on the ground moaning with left-sided weakness but able to answer questions. On arrival to the emergency department he remained neurologically stable. A head CT demonstrated a 5 mm right holohemispheric subdural hemorrhage. Neurosurgery was consulted and recommended initiation of an antiepileptic drug (AED). Valproic acid was started. Which of the following are concerns related to the use of valproic acid? A. It has the same early seizure prevention as phenytoin but it associates with improved mortality rate B. It is an inducer of the CYP system with multiple drug interactions C. It can result in acute renal injury and possible renal failure D. It can result in a coagulopathy which potentially could increase th. size of the patient's subdural hemorrhage.
Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter22: Anticonvulsants, Antiparkinsonian Drugs, And Agents For Alzheimer’s Disease
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