2 (a) Allylation is a powerful way to make compounds such as 8 and 9 diastereoselectively. он OH allylation Ph or Ph Ph H. (i) Allyl Grignard reagents [RCH=CHCH,MgBr] cannot be used to make 8 and 9 selectively. With the aid of a diagram explain why.

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2 (a) Allylation is a powerful way to make compounds such as 8 and 9 diastereoselectively.
OH
он
allylation
Ph
or
Ph
Ph
8
9
(i) Allyl Grignard reagents [RCH=CHCH,MgBr] cannot be used to make 8 and 9 selectively. With
the aid of a diagram explain why.
(ii) Which isomer of the allyl boronate 10 would you require to synthesise 8 selectively? Draw
and provide comments on the transition state of the allylation reaction of 10 with
benzaldehyde to support your answer.
B-O
10
Transcribed Image Text:2 (a) Allylation is a powerful way to make compounds such as 8 and 9 diastereoselectively. OH он allylation Ph or Ph Ph 8 9 (i) Allyl Grignard reagents [RCH=CHCH,MgBr] cannot be used to make 8 and 9 selectively. With the aid of a diagram explain why. (ii) Which isomer of the allyl boronate 10 would you require to synthesise 8 selectively? Draw and provide comments on the transition state of the allylation reaction of 10 with benzaldehyde to support your answer. B-O 10
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