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18. In order to m protein. You crea guide RNA comp sequence Gene that the CRISPR Gene Yis neces: a. Liver: F b. Liver: N

18. In order to m protein. You crea guide RNA comp sequence Gene that the CRISPR Gene Yis neces: a. Liver: F b. Liver: N

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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18. In order to modify DNA using a CRISPR/Cas9 system, you need a short guide RNA and Cas9 protein. You create a mouse line with Cas9 under control of a brain-specific enhancer, while the short guide RNA complementary to the first exon of Gene Y is expressed in all tissues. You subsequently sequence Gene Yin both brain and liver tissue. What would expect in each tissue? You can assume that the CRISPR/Cas9 system will impact both copies of Gene Y in cells, and that the first exon of Gene Yis necessary for Gene Y's function. a. Liver: Functional Gene Y; Brain: Functional Gene Y b. Liver: Nonfunctional Gene Y; Brain: Funtional Gene Y C. Liver: Functional Gene Y; Brain: Nonfunctional Gene Y d. Liver: Nonfunctional Gene Y; Brain: Nonfunctional Gene Y
Transcribed Image Text:18. In order to modify DNA using a CRISPR/Cas9 system, you need a short guide RNA and Cas9 protein. You create a mouse line with Cas9 under control of a brain-specific enhancer, while the short guide RNA complementary to the first exon of Gene Y is expressed in all tissues. You subsequently sequence Gene Yin both brain and liver tissue. What would expect in each tissue? You can assume that the CRISPR/Cas9 system will impact both copies of Gene Y in cells, and that the first exon of Gene Yis necessary for Gene Y's function. a. Liver: Functional Gene Y; Brain: Functional Gene Y b. Liver: Nonfunctional Gene Y; Brain: Funtional Gene Y C. Liver: Functional Gene Y; Brain: Nonfunctional Gene Y d. Liver: Nonfunctional Gene Y; Brain: Nonfunctional Gene Y
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