11. Treatment of compound F with lithium diisopropylamide followed by cyclohexanone gives either G or H. G is formed if the aldehyde is added at -78°C whereas H is formed if the aldehyde is added at 0°C. Furthermore, treatment of G with lithium diisopropylamide at 0°C gives H. Explain these results.

11. Treatment of compound F with lithium diisopropylamide followed by cyclohexanone gives either G or H. G is formed if the aldehyde is added at -78°C whereas H is formed if the aldehyde is added at 0°C. Furthermore, treatment of G with lithium diisopropylamide at 0°C gives H. Explain these results.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Concept explainers

Organomagnesium compounds

The interaction of alkyl halide with Mg metal in a suitable ether solvent is the common method for the synthesis of the Grignard reagent.

Hydrolysis Grignard Reactions and Reduction

Organomagnesium halides are Grignard reagents. Francois Auguste Victor Grignard, a French chemist who received the Nobel Prize in Chemistry in 1912, created these highly useful reagents.

Question

11. Treatment of compound F with lithium diisopropylamide followed by cyclohexanone
gives either G or H. G is formed if the aldehyde is added at -78°C whereas H is
formed if the aldehyde is added at 0°C. Furthermore, treatment of G with lithium
diisopropylamide at 0°C gives H. Explain these results.
CH2=CHCHCN
OCH₂CH₂OC₂H
F
H
OH
G
HO
CN
137
CCH=CH2
OCH2CH2OC2H5
PROBLEMS
CH2CH COCH2CH₂OC2H5
CN

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