10.38. The following data relate to an enzyme reaction. 10³[S]/mol dm³ 105 V/mol dm³ s-1 2.0 13 4.0 20 8.0 29 12.0 33 16.0 36 20.0 38 The concentration of the enzyme is 2.0 g dm³, and its molecular weight is 50 000. Calculate Km, the maximum rate V, and kc.
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
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*10.38. The following data relate to an enzyme reaction.
10³[S]/mol dm³ 105V/mol dm³ s-1
3
S
2.0
13
4.0
20
8.0
29
12.0
33
16.0
36
20.0
38
The concentration of the enzyme is 2.0 g dm3, and its
molecular weight is 50 000. Calculate Km, the maximum
rate V, and kc.
10.39. The following data have been obtained for the
myosin-catalyzed hydrolysis of ATP.
Temperature/°C kx 10s-1
39.9
4.67
43.8
7.22
47.1
10.0
50.2
13.9
Calculate, at 40 °C, the energy of activation, the enthalpy
of activation, the Gibbs energy of activation, and the
entropy of activation.
*10.40. The following is a simplified version of the mechanism
that has been proposed by H. Theorell and Britton Chance for
certain enzyme reactions involving two substrates A and B.
k₁
E + A EA
k-1
kr
EA + BEZ + Y
EZ E + Z
Assume that the substrates A and B are in excess of E so
that the steady-state treatment can be applied to EA and EZ,
and obtain an expression for the rate.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F9edf0456-b0b8-477c-9004-16982b2e7d76%2F84711867-b77f-4b9b-9160-85cfb31e5348%2F8vhn04d_processed.jpeg&w=3840&q=75)
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