10 Σχι = 285, i=1 b) c) 10 10 10 10 Σx = 8205, Σνι = 78.4, Σv = 6279, Σ×i = 2264.7 i=1 i=1 i=1 i=1 a) What is the best-fitting regression line relating mean thyroxine level to gestational age? Interpret the meaning of the slope b in this problem. Is there a significant association between mean thyroxine level and gestational age? Report a p-valu (Hint: Test whether p-value < 0.001)

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### Investigating the Relationship Between Gestational Age and Thyroxine Levels in Premature Infants

#### Study Background

A study was conducted to determine whether hypothyroxinemia in premature infants is a cause of subsequent motor and cognitive abnormalities. The following dataset was produced:

| Gestational Age, \(x\) (weeks) | Mean Thyroxine Levels, \(y\) (µg/dL) |
|--------------------------------|-------------------------------------|
| ≤ 24                           | 6.5                                 |
| 25                             | 7.1                                 |
| 26                             | 7.0                                 |
| 27                             | 7.1                                 |
| 28                             | 7.2                                 |
| 29                             | 7.1                                 |
| 30                             | 8.1                                 |
| 31                             | 8.7                                 |
| 32                             | 9.5                                 |
| 33                             | 10.1                                |

Additional summations helpful for analysis are given below:

\[ \sum_{i=1}^{10} x_i = 285, \]
\[ \sum_{i=1}^{10} x_i^2 = 8205, \]
\[ \sum_{i=1}^{10} y_i = 78.4, \]
\[ \sum_{i=1}^{10} y_i^2 = 627.9, \]
\[ \sum_{i=1}^{10} x_i y_i = 2264.7. \]

#### Questions and Analysis:

##### a) What is the best-fitting regression line relating mean thyroxine level to gestational age?

The best-fitting regression line can be determined using the linear regression formula:

\[ y = a + bx \]

Where the slope \( b \) and intercept \( a \) are calculated as follows:

\[ b = \frac{n\sum (xy) - (\sum x)(\sum y)}{n\sum x^2 - (\sum x)^2} \]
\[ a = \frac{\sum y - b\sum x}{n} \]

Using the given data:
\[ n = 10 \]
\[ \sum x = 285 \]
\[ \sum y = 78.4 \]
\[ \sum x^2 = 8205 \]
\[ \sum xy = 2264.7 \]

\[ b = \frac{10
Transcribed Image Text:### Investigating the Relationship Between Gestational Age and Thyroxine Levels in Premature Infants #### Study Background A study was conducted to determine whether hypothyroxinemia in premature infants is a cause of subsequent motor and cognitive abnormalities. The following dataset was produced: | Gestational Age, \(x\) (weeks) | Mean Thyroxine Levels, \(y\) (µg/dL) | |--------------------------------|-------------------------------------| | ≤ 24 | 6.5 | | 25 | 7.1 | | 26 | 7.0 | | 27 | 7.1 | | 28 | 7.2 | | 29 | 7.1 | | 30 | 8.1 | | 31 | 8.7 | | 32 | 9.5 | | 33 | 10.1 | Additional summations helpful for analysis are given below: \[ \sum_{i=1}^{10} x_i = 285, \] \[ \sum_{i=1}^{10} x_i^2 = 8205, \] \[ \sum_{i=1}^{10} y_i = 78.4, \] \[ \sum_{i=1}^{10} y_i^2 = 627.9, \] \[ \sum_{i=1}^{10} x_i y_i = 2264.7. \] #### Questions and Analysis: ##### a) What is the best-fitting regression line relating mean thyroxine level to gestational age? The best-fitting regression line can be determined using the linear regression formula: \[ y = a + bx \] Where the slope \( b \) and intercept \( a \) are calculated as follows: \[ b = \frac{n\sum (xy) - (\sum x)(\sum y)}{n\sum x^2 - (\sum x)^2} \] \[ a = \frac{\sum y - b\sum x}{n} \] Using the given data: \[ n = 10 \] \[ \sum x = 285 \] \[ \sum y = 78.4 \] \[ \sum x^2 = 8205 \] \[ \sum xy = 2264.7 \] \[ b = \frac{10
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