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1.A patient is taking nifedipine 20 mg three times daily. Assuming 100% bioavailability, how much nifedipine is eliminated from this patient's body every 24 hours at steady state? Please expain

1.A patient is taking nifedipine 20 mg three times daily. Assuming 100% bioavailability, how much nifedipine is eliminated from this patient's body every 24 hours at steady state? Please expain

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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AutoSave hmm OFF Home Insert Draw Design Layout References Mailings Review View Acrobat Tell me Share O Comments Helvetica N... v 12 A A Аa v AaBbCcDc AaBbCcDdE AaBb( AaBbCcDdEe AaBbCcDdEe > ev Av No Spacing Styles Pane Dictate Create and Share Adobe PDF Paste A Request Signatures I U v ab x, Normal Heading 1 Heading 2 Title X Renew Your Subscription To keep using your Office applications without interruption, please renew by Friday, October 30, 2020. Buy 1.A patient is taking nifedipine 20 mg three times daily. Assuming 100% bioavailability, how much nifedipine is eliminated from this patient's body every 24 hours at steady state? Please expain 2. A female patient (48 years old, 70 kg) with an acute exacerbation of asthma is taken to the emergency department in severe distress. The emergency physician decides to begin aminophylline therapy by administration of a 450 mg IV aminolehuline loading dose followed by a continuous infusion of aminophylline. Pharmacokinetic data for aminophylline: Volume of distribution= 0.5 L/kg or 35L (for 70kg person) • Target concentration = 10-15 mg/L Elimination half-life = 20 hours Bioavailability = 90% Protein Binding = 40% -Explain the purpose for an aminophylline loading dose in this patient before starting a continuous IV infusion of aminophylline? -If the clinical staff forgets to begin the aminophylline continuous infusion after the aminophylline loading dose, then approximately how many hours will it take for the aminophylline blood concentration to fall below the therapeutic range? Show your calculation or explain how you answered this question. -What is the oral maintenance dose required for this patient, dosed twice per day? Show your calculation or explain how you answered this question. 3. A patient is taking felodipine once daily. Felodipine is extensively metabolized by CYP3A4. About two weeks ago this patient also started taking carbamazepine orally twice daily. Carbamazepine is a potent inducer of CYP3A4. What are the changes associated with felodipine pharmacokinetics that would have occurred over the last two weeks in this patient? -Which of the following best describes the impact of carbamazepine on the percent of felodipine metabolized -Which of the following best describes the impact of carbamazepine on the volume of distribution of felodipine? -Which of the following best describes the impact of carbamazepine on plasma concentrations of felodipine -Which of the following best describes the impact of carbamazepine on the half-life of felodipine? -Which of the following best describes the impact of carbamazepine on Page 1 of 2 338 words English (United States) EO Focus 106% lili
Transcribed Image Text:AutoSave hmm OFF Home Insert Draw Design Layout References Mailings Review View Acrobat Tell me Share O Comments Helvetica N... v 12 A A Аa v AaBbCcDc AaBbCcDdE AaBb( AaBbCcDdEe AaBbCcDdEe > ev Av No Spacing Styles Pane Dictate Create and Share Adobe PDF Paste A Request Signatures I U v ab x, Normal Heading 1 Heading 2 Title X Renew Your Subscription To keep using your Office applications without interruption, please renew by Friday, October 30, 2020. Buy 1.A patient is taking nifedipine 20 mg three times daily. Assuming 100% bioavailability, how much nifedipine is eliminated from this patient's body every 24 hours at steady state? Please expain 2. A female patient (48 years old, 70 kg) with an acute exacerbation of asthma is taken to the emergency department in severe distress. The emergency physician decides to begin aminophylline therapy by administration of a 450 mg IV aminolehuline loading dose followed by a continuous infusion of aminophylline. Pharmacokinetic data for aminophylline: Volume of distribution= 0.5 L/kg or 35L (for 70kg person) • Target concentration = 10-15 mg/L Elimination half-life = 20 hours Bioavailability = 90% Protein Binding = 40% -Explain the purpose for an aminophylline loading dose in this patient before starting a continuous IV infusion of aminophylline? -If the clinical staff forgets to begin the aminophylline continuous infusion after the aminophylline loading dose, then approximately how many hours will it take for the aminophylline blood concentration to fall below the therapeutic range? Show your calculation or explain how you answered this question. -What is the oral maintenance dose required for this patient, dosed twice per day? Show your calculation or explain how you answered this question. 3. A patient is taking felodipine once daily. Felodipine is extensively metabolized by CYP3A4. About two weeks ago this patient also started taking carbamazepine orally twice daily. Carbamazepine is a potent inducer of CYP3A4. What are the changes associated with felodipine pharmacokinetics that would have occurred over the last two weeks in this patient? -Which of the following best describes the impact of carbamazepine on the percent of felodipine metabolized -Which of the following best describes the impact of carbamazepine on the volume of distribution of felodipine? -Which of the following best describes the impact of carbamazepine on plasma concentrations of felodipine -Which of the following best describes the impact of carbamazepine on the half-life of felodipine? -Which of the following best describes the impact of carbamazepine on Page 1 of 2 338 words English (United States) EO Focus 106% lili
AutoSave hmm OFF Home Insert Draw Design Layout References Mailings Review View Acrobat Tell me Share O Comments Helvetica N... v 12 A A Аa v AaBbCcDc AaBbCcDdE AaBb( AaBbCcDdEe AaBbCcDdEe > ev Av Styles Pane Dictate Create and Share Adobe PDF Paste No Spacing A Request Signatures I U v ab x, Normal Heading 1 Heading 2 Title O Renew Your Subscription To keep using your Office applications without interruption, please renew by Friday, October 30, 2020. Buy 3. A patient is taking felodipine once daily. Felodipine is extensively metabolized by CYP3A4. About two weeks ago this patient also started taking carbamazepine orally twice daily. Carbamazepine is a potent inducer associated with felodipine pharmacokinetics that would have occurred over the last two weeks in this patient? CYP3A4. What are the changes -Which of the following best describes the impact of carbamazepine on the percent of felodipine metabolized -Which of the following best describes the impact of carbamazepine on the volume of distribution of felodipine? -Which of the following best describes the impact of carbamazepine on plasma concentrations of felodipine -Which of the following best describes the impact of carbamazepine on the half-life of felodipine? -Which of the following best describes the impact of carbamazepine on the clearance of felodipine? Group of answer choices No change Decrease Increase Page 1 of 2 338 words English (United States) E 3 Focus 106% lili
Transcribed Image Text:AutoSave hmm OFF Home Insert Draw Design Layout References Mailings Review View Acrobat Tell me Share O Comments Helvetica N... v 12 A A Аa v AaBbCcDc AaBbCcDdE AaBb( AaBbCcDdEe AaBbCcDdEe > ev Av Styles Pane Dictate Create and Share Adobe PDF Paste No Spacing A Request Signatures I U v ab x, Normal Heading 1 Heading 2 Title O Renew Your Subscription To keep using your Office applications without interruption, please renew by Friday, October 30, 2020. Buy 3. A patient is taking felodipine once daily. Felodipine is extensively metabolized by CYP3A4. About two weeks ago this patient also started taking carbamazepine orally twice daily. Carbamazepine is a potent inducer associated with felodipine pharmacokinetics that would have occurred over the last two weeks in this patient? CYP3A4. What are the changes -Which of the following best describes the impact of carbamazepine on the percent of felodipine metabolized -Which of the following best describes the impact of carbamazepine on the volume of distribution of felodipine? -Which of the following best describes the impact of carbamazepine on plasma concentrations of felodipine -Which of the following best describes the impact of carbamazepine on the half-life of felodipine? -Which of the following best describes the impact of carbamazepine on the clearance of felodipine? Group of answer choices No change Decrease Increase Page 1 of 2 338 words English (United States) E 3 Focus 106% lili
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