1.2i. Describe the relationship between partitionconstant and partition ratio.ii. briefly discuss types of extraction methods usedin chemical analysis.iii. Briefly discuss the elution chromatography oncolumns (use a diagram to illustrate youranswer).

1. Partition Constant (K): The partition constant, often denoted as K, is a measure of the…

Answered: 1.2 i. Describe the relationship…

Principles of Instrumental Analysis

7th Edition

ISBN:9781305577213

Author:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Publisher:Douglas A. Skoog, F. James Holler, Stanley R. Crouch

Chapter28: High-performance Liquid Chromatography

Section: Chapter Questions

Problem 28.2QAP

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6. ( If the solubility of solute Z is 1.0 g/60 mL in diethyl ether and is 1.0 g/1110 mL in water. a) Determine the partition coefficient for the solute Z in these two solvents. b) If 60 mg of the solute Z were dissolved in 100 mL of water, how much ether would be required to extract 90% of solute Z in a single extraction. c) What percent of the A would be extracted from the aqueous solution in (b) by two 50 mL portions of ether?
Solute A has a partition coefficient of 3 between toluene and water, with three times as much in the toluene phase. Suppose that 100 mL of a 0.010M aqueous solution of A is extracted with toluene. What fraction of A remains in the aqueous phase, if five extraction with 100 mL is performed?
You add 1 mL of sample and collect 1 mL fractions from a column with a volume of 20 mL where the beads take up 60% of the column and the protein of interest has a partition coefficient of 0.4. What fraction do you want to keep?
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2. Solute A has a partition coefficient of 4 between diethyl ether and water. If 100 mL of 0.1 M aqueous solution of A is extracted twice with 100 mL of diethyl ether, what is the resulting concentration of A in aqueous layer? (Please show the solution of the correct answer) A. 2.0x10^-3 M B. 4.0x10^-3 M C. 2.0x10^-2 M D. 2.0x10^-2 M
1. It can be shown mathematically that 2 or more smaller extractions (using smaller portions of asolvent) are better than 1 single extraction using a larger portion of solvent. Suppose a particularextraction proceeds with a partition coefficient, Ksp, of 10. Ksp = C2/C1 where C2/C1 is the distribution of a compound between diethyl ether (C2) andwater (C1) in grams/L. Use grams/L in your calculations. 5.00 g of an organic compound is dissolved in 100 ml of water. Show that two successive 50.0 mlextractions with diethyl ether will yield more compound than one 100 ml extraction.
Please don't provide handwritten solution ....
Assume an organic compound has a partition coefficient between water and ether equal to 7.34. If there are initially 8.67 g of the compound dissolved in 70.0 mL of water, how many grams will remain in the aqueous layer after each extraction with three 15.0 mL portions of ether? mass remaining after the first extraction: mass remaining after the second extraction: mass remaining after the third extraction: g g 5.0 g
Note: Answer Letter B only, refer to the first problem for the given data in order to answer B
1. Calculate the capacity factor, k' for methyl paraben and propyl paraben. 2. Calculate the selectivity factor, a for the two-component mixture.

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1.2 i. Describe the relationship between partition constant and partition ratio. ii. briefly discuss types of extraction methods used in chemical analysis. iii. Briefly discuss the elution chromatography on columns (use a diagram to illustrate your answer).