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- Discuss both intrinsic and environmental factors influencing the biotransformation of drugs. (20 Marks)54. The volume of distribution of a drug is 350 L. Which of the following is most likely to account for this volume of distribution? OA) Extensive binding to tissue proteins B) Extensive hepatic metabolism C) Inability to cross the blood-brain barrier D) Low lipid solubility E) Rapid renal excretion27. In a life-threatening situation when a therapeutic concentration of a drug is needed immediately, which of the following is the best means for choosing the loading dose? A) Bolus of five times the maintenance dose B) Infusion at five times the normal maintenance rate for 1 half-life C) Maintenance dose times body weight D) Maintenance doses with the dose interval equal to the half-life E) Steady-state plasma concentration times the volume of distribution
- 3. Under what circumstances shouldn't Cetirizine be used?2. Discuss the difference between first-generation and second-generation antihistamines. 3. When dispensing antihistamine drugs, what auxiliary label must be attached to the product? Explain its importance.3. Describe the mechanism of action of a "statin" drug. What are some of the complications that could occur from administration of a "statin" drug?