1. Twelve families are selected for a genetic linkage study because of a high prevalence of disease. A genome screen is performed, using anonymous DNA markers on all autosomes. Significant evidence is observed for linkage to a marker on chromosome 2 (D2S123) in four families. The LOD score for the remaining families at this locus is significantly negative. How do you interpret this finding? Ans: There is likely to be more than one gene that can be inherited in altered form to increase risk for disease. The technical term for inheritance of more than one gene is genetic heterogeneity-different genes exist; further research is needed to identify remaining candidate regions. Inheritance of more than one gene was illustrated with the breast cancer example and how two genes (BRCA1 and BRCA2) were mapped

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