1. The structure below is Budesonide, a glucocorticoid that comprises half of the asthma inhaler Symbicort (the other half is detailed in Q3) used for maintenance therapy. OH HO, Redraw the structure, labelling the hybridization for all atoms.
Formal Charges
Formal charges have an important role in organic chemistry since this concept helps us to know whether an atom in a molecule is neutral/bears a positive or negative charge. Even if some molecules are neutral, the atoms within that molecule need not be neutral atoms.
Polarity Of Water
In simple chemical terms, polarity refers to the separation of charges in a chemical species leading into formation of two polar ends which are positively charged end and negatively charged end. Polarity in any molecule occurs due to the differences in the electronegativities of the bonded atoms. Water, as we all know has two hydrogen atoms bonded to an oxygen atom. As oxygen is more electronegative than hydrogen thus, there exists polarity in the bonds which is why water is known as a polar solvent.
Valence Bond Theory Vbt
Valence bond theory (VBT) in simple terms explains how individual atomic orbitals with an unpaired electron each, come close to each other and overlap to form a molecular orbital giving a covalent bond. It gives a quantum mechanical approach to the formation of covalent bonds with the help of wavefunctions using attractive and repulsive energies when two atoms are brought from infinity to their internuclear distance.
**Chemical Structure Explanation:**
- The structure consists of several fused rings, characteristic of steroids.
- There are two hydroxyl groups (-OH) attached to the ring systems.
- Additional functional groups and side chains include a ketone group (=O) and various carbon chains.
**Assignment Task:**
- Redraw the structure of Budesonide.
- Label the hybridization for all atoms in the compound.
For a deeper understanding, you can explore the molecular structures of similar glucocorticoids and their functional groups. This knowledge will aid in understanding how such structures influence the therapeutic effects of the medication.
Please refer to question 3 (Q3) for details on the other half of Symbicort's active ingredients.
##### Additional Reading:
- [Understanding Glucocorticoids](link_to_article)
- [Mechanism of Action of Budesonide](link_to_article)
- [Asthma Management with Symbicort](link_to_article)](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fe4299fda-4eca-4f5e-9eb2-cd6160b169dc%2Fa920dcb5-ec43-4d7e-9d2f-e300c6574860%2F83z60xp_processed.jpeg&w=3840&q=75)
Step by step
Solved in 2 steps with 1 images
