1. Teresa is a 4-month old girl who suffers from acute heart failure. She urgently needs a cadaver heart to carry out a heart transplant or her life will be in danger. Teresa has type O blood. A mother would like to donate the heart of her 16-year old daughter, who just died in a serious car accident. Her daughter also has type O blood. However, she is not qualified as a heart donor for Teresa. Fortunately, a donor of type AB blood is found one week later, and the heart transplant is done successfully with no signs of serious graft rejection. (a) Apart from blood group testing, describe the procedure of an additional test that should be done to reduce the chance of graft rejection. (b) Give three possible reasons to explain why the 16-year old girl is not a suitable heart donor for Teresa, despite they both have the same blood type. (c) Explain why a donor with any blood type (e.g. type AB blood in this case) can be considered acceptable for Teresa. (d) Name one class of drug that should be given to Teresa after the heart transplant. Briefly explain its mechanism of action.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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1. Teresa is a 4-month old girl who suffers from acute heart failure. She urgently needs a
cadaver heart to carry out a heart transplant or her life will be in danger. Teresa has type
O blood.
A mother would like to donate the heart of her 16-year old daughter, who just died in a
serious car accident. Her daughter also has type O blood. However, she is not qualified as
a heart donor for Teresa. Fortunately, a donor of type AB blood is found one week later,
and the heart transplant is done successfully with no signs of serious graft rejection.
(a) Apart from blood group testing, describe the procedure of an additional test that
should be done to reduce the chance of graft rejection.
(b) Give three possible reasons to explain why the 16-year old girl is not a suitable heart
donor for Teresa, despite they both have the same blood type.
(c) Explain why a donor with any blood type (e.g. type AB blood in this case) can be
considered acceptable for Teresa.
(d) Name one class of drug that should be given to Teresa after the heart transplant.
Briefly explain its mechanism of action.
Transcribed Image Text:1. Teresa is a 4-month old girl who suffers from acute heart failure. She urgently needs a cadaver heart to carry out a heart transplant or her life will be in danger. Teresa has type O blood. A mother would like to donate the heart of her 16-year old daughter, who just died in a serious car accident. Her daughter also has type O blood. However, she is not qualified as a heart donor for Teresa. Fortunately, a donor of type AB blood is found one week later, and the heart transplant is done successfully with no signs of serious graft rejection. (a) Apart from blood group testing, describe the procedure of an additional test that should be done to reduce the chance of graft rejection. (b) Give three possible reasons to explain why the 16-year old girl is not a suitable heart donor for Teresa, despite they both have the same blood type. (c) Explain why a donor with any blood type (e.g. type AB blood in this case) can be considered acceptable for Teresa. (d) Name one class of drug that should be given to Teresa after the heart transplant. Briefly explain its mechanism of action.
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