1. Requirements of Active Sites in Enzymes The active site of an enzyme usually consists of a pocket on the enzyme surface lined with amino acid side chains necessary to bind the substrate and catalyze its chemical transformation. Carboxypeptidase, which sequentially removes the carboxyl-terminal amino acid residues from its peptide substrates, consists of a síngle chain of 307 amino acids. The two essential catalytic groups in the active site are furnished by Arg145 and Glu²7º. (a) If the carboxpeptidase chain were a perfect a-helix, how far apart (in nanometers) would Arg45 and Glu²7º be? Hint: In an æ-helix, there is 1.5 Å translation of the backbone per residue (Chapter 3). (b) Explain how it is that these two amino acids, so distantly separated in the sequence, can catalyze a reaction occurring in the space of a few tenths of a nanometer. ,270
1. Requirements of Active Sites in Enzymes The active site of an enzyme usually consists of a pocket on the enzyme surface lined with amino acid side chains necessary to bind the substrate and catalyze its chemical transformation. Carboxypeptidase, which sequentially removes the carboxyl-terminal amino acid residues from its peptide substrates, consists of a síngle chain of 307 amino acids. The two essential catalytic groups in the active site are furnished by Arg145 and Glu²7º. (a) If the carboxpeptidase chain were a perfect a-helix, how far apart (in nanometers) would Arg45 and Glu²7º be? Hint: In an æ-helix, there is 1.5 Å translation of the backbone per residue (Chapter 3). (b) Explain how it is that these two amino acids, so distantly separated in the sequence, can catalyze a reaction occurring in the space of a few tenths of a nanometer. ,270
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter6: Energy, Enzymes, And Biological Reactions
Section: Chapter Questions
Problem 8TYK: Which of the following statements about the allosteric site is true? a. The allosteric site is a...
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