Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
Provide the missing reagents and products for each transformation shown below.
Alkene reacts with mCPBA and give epoxide as product.
Phenyllithium is a good source of phenyl anion.
PCC is a mild oxidizing agent. It oxidizes secondary alcohol to ketone.
LAH is a reducing agent it reduces ketone to secondary alcohol.
Grignard reagent reacts with ketone in acid medium and give -alcohol as product.
NaH and reacts with alcohol and give ether as product.
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