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1. Hexokinase and Glucokinase are two enzymes that catalyze the first reaction of glycolysis: Glucose + ATP à Glucose-6-phosphate + ADP. The Km for Hexokinase is 0.15 mM and the Km for Glucokinase is 10 mM.

1. Hexokinase and Glucokinase are two enzymes that catalyze the first reaction of glycolysis: Glucose + ATP à Glucose-6-phosphate + ADP. The Km for Hexokinase is 0.15 mM and the Km for Glucokinase is 10 mM.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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1. Hexokinase and Glucokinase are two enzymes that catalyze the first reaction of glycolysis: Glucose + ATP à Glucose-6-phosphate + ADP. The Km for Hexokinase is 0.15 mM and the Km for Glucokinase is 10 mM. a. Draw curves of the enzyme velocity vs. substrate concentration for Hexokinase and Glucokinase using the graph paper. Label both axes and identify where you would find Vmax, and Km for both enzymes. b. Which of the two enzymes most likely has a higher affinity for glucose? c. Which enzyme catalyzes the formation of Glucose-6- phosphate more quickly? d. Glucokinase is present in the liver, whereas Hexokinase is expressed in most other tissues. Normal blood sugar levels are ~5 mM after fasting (e.g. waking up in the morning) and ~8 mM 2 hours after eating a meal. Given this information, predict when hexokinase and glucokinase are most likely most active in the body?
Transcribed Image Text:1. Hexokinase and Glucokinase are two enzymes that catalyze the first reaction of glycolysis: Glucose + ATP à Glucose-6-phosphate + ADP. The Km for Hexokinase is 0.15 mM and the Km for Glucokinase is 10 mM. a. Draw curves of the enzyme velocity vs. substrate concentration for Hexokinase and Glucokinase using the graph paper. Label both axes and identify where you would find Vmax, and Km for both enzymes. b. Which of the two enzymes most likely has a higher affinity for glucose? c. Which enzyme catalyzes the formation of Glucose-6- phosphate more quickly? d. Glucokinase is present in the liver, whereas Hexokinase is expressed in most other tissues. Normal blood sugar levels are ~5 mM after fasting (e.g. waking up in the morning) and ~8 mM 2 hours after eating a meal. Given this information, predict when hexokinase and glucokinase are most likely most active in the body?
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