3. Through directed evolution, enzymes can be designed in laboratories to catalyze new desired reactions. This research idea led to a share of the Nobel Prize in Chemistry to be awarded to Frances Arnold in 2018. You have just evolved and isolated an enzyme which can catalyze the following reaction. Draw arrow pushing mechanism to describe the following transformation. Use B: and HA as surrogates for basic/acidic amino acid residues. H Enzyme 1. Fill in the box with the missing starting material(s), reagent(s), or product(s): 四 1.2 1.3 1.4 1.5 WOH Br 1eq. 1eq. HB AICI 3 LDA /MOD 8445

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Chapter1: Chemical Foundations
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Do question 1.5 from the problem 1 only. And complete question 3 as well.

3. Through directed evolution, enzymes can be designed in laboratories to catalyze new
desired reactions. This research idea led to a share of the Nobel Prize in Chemistry to
be awarded to Frances Arnold in 2018. You have just evolved and isolated an enzyme
which can catalyze the following reaction. Draw arrow pushing mechanism to describe
the following transformation. Use B: and HA as surrogates for basic/acidic amino acid
residues.
H
Enzyme
Transcribed Image Text:3. Through directed evolution, enzymes can be designed in laboratories to catalyze new desired reactions. This research idea led to a share of the Nobel Prize in Chemistry to be awarded to Frances Arnold in 2018. You have just evolved and isolated an enzyme which can catalyze the following reaction. Draw arrow pushing mechanism to describe the following transformation. Use B: and HA as surrogates for basic/acidic amino acid residues. H Enzyme
1. Fill in the box with the missing starting material(s), reagent(s), or product(s):
四
1.2
1.3
1.4
1.5
WOH
Br
1eq.
1eq. HB
AICI 3
LDA
/MOD
8445
Transcribed Image Text:1. Fill in the box with the missing starting material(s), reagent(s), or product(s): 四 1.2 1.3 1.4 1.5 WOH Br 1eq. 1eq. HB AICI 3 LDA /MOD 8445
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