1- Write Walden's Cycle of Reactions Interconverting. 2- Mention the product of a nucleophilic substitution reaction of (S)-2- bromohexane with acetate ion, CH3CO2- Assume that inversion of configuration occurs, and show the chemistry of both the reactant and product. 3- Draw the mechanism of the SN2 Reaction. Show the correct directions of the arrows, and all reagents. 4- Draw the mechanism of the SN1 Reaction. Show the correct directions of the arrows, and all reagents. 5- Draw the mechanism of the E2 Reaction with an Alkyl Halide. Show the correct directions of the arrows, and all reagents. 6- Draw the mechanism of the E1 Reaction with an Alkyl Halide. Show the correct directions of the arrows, and all reagents. 7- Mention the product formed in an SN2 reaction between 1- bromobutane and Nal. 8- Rank the following compounds in order of their expected reactivity toward SN2 reaction: CH3Br, CH3OTOs, (CH3)2CHC1. 9- Explain Grignard Reagents in details with one example. 10- Mention how a halogen substituent can be replaced by a deuterium atom in the preparation of a deuterated compound. Br | CH3CHCH₂CH3 ? D I CH3CHCH₂CH3

1- Write Walden's Cycle of Reactions Interconverting. 2- Mention the product of a nucleophilic substitution reaction of (S)-2- bromohexane with acetate ion, CH3CO2- Assume that inversion of configuration occurs, and show the chemistry of both the reactant and product. 3- Draw the mechanism of the SN2 Reaction. Show the correct directions of the arrows, and all reagents. 4- Draw the mechanism of the SN1 Reaction. Show the correct directions of the arrows, and all reagents. 5- Draw the mechanism of the E2 Reaction with an Alkyl Halide. Show the correct directions of the arrows, and all reagents. 6- Draw the mechanism of the E1 Reaction with an Alkyl Halide. Show the correct directions of the arrows, and all reagents. 7- Mention the product formed in an SN2 reaction between 1- bromobutane and Nal. 8- Rank the following compounds in order of their expected reactivity toward SN2 reaction: CH3Br, CH3OTOs, (CH3)2CHC1. 9- Explain Grignard Reagents in details with one example. 10- Mention how a halogen substituent can be replaced by a deuterium atom in the preparation of a deuterated compound. Br | CH3CHCH₂CH3 ? D I CH3CHCH₂CH3

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 8E

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