1) Show how to use solid phase techniques to synthesize Ala-Val-Phe. You may use any amino acids (including protected amino acids) and any inorganic reagents that you wish in carrying out your synthesis. You don't need to show any mechanisms for this synthesis. You can maximize your chances of partial credit by showing key intermediates. (12 points)

14. What is the mechanism of the reaction (E1, E2, SN1, or SN2) that occurs when t-butyl alcohol (shown below) reacts with HI? (3 pts) OH + HI????

X 10 (select) v molecules of penicillin

1. Propose a mechanism for the following reaction. (10 points) Br₂ OH Br 29. on HBr

(12) Calculate the pK, of dichloroacetate. Formulate the base association equilibrium for dichloroacetate. Consider the acid dissociation equilibrium: Ka = ChCHCOO- + H+ Cl2CHCOOH Ka = 2.71 · 10-11

9. Phosphotyrosine (shown below) has four ionizable functional groups (pK1 = 2.5, pKR1 = 2.1, pKr2 = 7.2, pK2 = 9.5). (a) Write the equilibrium equation for its four ionization forms and assign the proper pka for each ionization. DRAW the structure of phosphotyrosine in each ionization state. What is the net charge on the phosphotyrosine molecule in each ionization state? *H3N. pk2 - 9.5 .COOH pK, - 2.5 O=P-OH pKRI - 2.1 ÖH pKRI - 7.2 (b) Draw the titration curve of phosphorotyrosine and indicate each pKa and the isoelectric point (pl), indicate the molar equivalents of OH on the x-axis.

Directions: Identify the type of IMFA for the following substances and answer the questions that follow. You may follow the examples above in answering the questions. Table 1-Substances and IMFA Types 1. CO 2. NH3 3. CCIA Critical Thinking Questions: 1. How do you determine the type of IMFA that in each of the given substances? OCcurs 2. Rank the strength of each compound based on IMFA. (1 = strongest, 2 = in between, 3 = weakest) Explain your answer. 1. %3D %3D

The pKa of acetone, CH;COCH3, is 19.3. Which of the following bases is strong enough to deprotonate acetone? Explain your answer. 1. (а) КОН (рКа ofH-O — 15.7) (b) Na* (с) NaHCO: (pKа of H-COз %3D 6.4) (d) NaOCH; (pKa of CH;OH= 15.6) C = CH (pKa of C2H2 = 25)

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10:27 0 A shop O O 7 l 87% i AIATS For Two Year Medic. A 48 /180 (02:56 hr min Mark for Review Which of the following compounds can exhibit tautomerism? OH Clear Response II III