1) Show how to use solid phase techniques to synthesize Ala-Val-Phe. You may use any amino acids (including protected amino acids) and any inorganic reagents that you wish in carrying out your synthesis. You don't need to show any mechanisms for this synthesis. You can maximize your chances of partial credit by showing key intermediates. (12 points)

(4 pts) a) a) Name these compounds Amines w HCI H₂N none properly: bon 29e soluble HCO, Na b) pts) Which of the following would give a positive coe b) acetone d) cyclopentanone H₂C CH3 aqu NH CH3 datioase term is use phenyl an efter b) basic hydrolysis of an ester nide For each of the above label it as a 1° 2° or 3º ami

3. Draw the acid-base reaction products of sodium hydride and ethanol. Show using a curved arrow notation how the products are generated. Given the pKa values below, show using the equilibrium arrow where the reaction will proceed (forward or backward process). Justify your answer. (7 PTS) Na* :H CH3CH₂-O-H Sodium hydride Ethanol Selected pK, Values Acid H-CI CH₂COO-H HO-H CHỊCH,O-H HCECH H-H H₂N-H CH₂=CH₂ CH₂-H pk₂ -7 4.8 15.7 16 25 35 38 44 50 Conjugate base СГ CH₂COO™ HO™ CH,CH,O HC=C H H₂N™ CH₂=CH CH₂

PP is also taking Advicor, which is a combination product containing extended-release niacin (vitamin B3) and lovastatin. Identfy the ionizable groups in niacin's structure below, and select the correct choice from the the dropdown menu that matches the overall net charge of niacin at each anatomical location HO, Stomach (pH = 1) (1 Intestines (pH = 7) (2 Answers 1-2 1. Select answer choice 2. Select answer choice

a) Draw the curly arrow mechanism to show a proton transfer between benzoic acid and the salt sodium ethoxide (C₂H, ONA): b) Amino acids can exist in two possible forms (shown) i) Explain the position of the following equilibrium: OH R NH₂ H R NH3 H ii) Predict, giving reasons, the melting point of amino acids compared to other similar mass hydrogen bonded organics such as amines and diols.

109) Complete the following acid/base reaction and use pKa or pKb values to predict whether the equilibrium will favor the reactants or products: -OH pka = 10.0 Answer: + CH3CH₂SO pk = 3.5

X 10 (select) v molecules of penicillin

3. Which is the stronger acid: (a) Benzoic acid with a Ka of 6.5 x10-5 or hydrocyanic acid with a Ka of 4.9 x 10-10? (b) Boric acid with a pKa of 9.14 or carbonic acid with a pKa of 6.37

Please answer all 3

Please see attached image