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1) Phosphofructokinase-1 (PFK-1) catalyzes the 3rd step of glycolysis, which is the committed step. Thus, PFK-1 is an excellent target for tight control of the glycolytic pathway. A) What factors act as positive allosteric modulators of PFK-1? B) What factors act as negative allosteric modulators of PFK-1? C) Of the positive allosteric modulators, which factor is homotropic? D) Where on PFK-1 do these factors bind?

1) Phosphofructokinase-1 (PFK-1) catalyzes the 3rd step of glycolysis, which is the committed step. Thus, PFK-1 is an excellent target for tight control of the glycolytic pathway. A) What factors act as positive allosteric modulators of PFK-1? B) What factors act as negative allosteric modulators of PFK-1? C) Of the positive allosteric modulators, which factor is homotropic? D) Where on PFK-1 do these factors bind?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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1) Phosphofructokinase-1 (PFK-1) catalyzes the 3rd step of glycolysis, which is the committed step. Thus, PFK-1 is an excellent target for tight control of the glycolytic pathway. A) What factors act as positive allosteric modulators of PFK-1? B) What factors act as negative allosteric modulators of PFK-1? C) Of the positive allosteric modulators, which factor is homotropic? D) Where on PFK-1 do these factors bind?
Transcribed Image Text:1) Phosphofructokinase-1 (PFK-1) catalyzes the 3rd step of glycolysis, which is the committed step. Thus, PFK-1 is an excellent target for tight control of the glycolytic pathway. A) What factors act as positive allosteric modulators of PFK-1? B) What factors act as negative allosteric modulators of PFK-1? C) Of the positive allosteric modulators, which factor is homotropic? D) Where on PFK-1 do these factors bind?
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