. Williamson Ether Synthesis Questions for lab , Synthesize phenacetin from acetaminophen (Tylenol) via a Williamson ether synthesis. a.Find the missing reagent: CH3CH2OH +? → C2H5OC2H5 H2SO4,
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a.Find the missing reagent:
CH3CH2OH +? → C2H5OC2H5
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H2SO4, |
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H2O |
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HNO3, |
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H2CO3 |
b.What is the nucleophile in this reaction?
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H2O |
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Nu- |
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RO- |
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ROH |
c.If you wanted to prepare Guaifenesin (present in OTC cough meds), choose the alcohol you would start with?
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2 methoxy benzoinc acid |
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2-methoxy benzaldehyde |
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2-methoxyphenol |
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2 methoxy anisole |
d.What was the mechanism of the reaction you used to prepare the ether?
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SN1 |
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SN2 |
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E1 |
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E2 |
e.The reaction given below is known as by which o the following reaction?
C2H5ONa+IC2H5→C2H5OC2H5+NaI
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Oxidation reaction |
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Williamson reduction reaction |
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Williamson ether synthesis |
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Wittig synthesis |
f.Chloroethane reacts with X to form diethyl ether. What is X?
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Sodium carbonate |
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Sodium ethoxide |
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Sulfuric acid |
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Sodium chloride |
j.Which of the following will facilitate this reaction?
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Strong nucleophile |
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slow leaving group |
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Bulky groups |
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tertiary |
k.What is the rate determining step of this reaction?
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Formation of carbocation |
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Formation of the transition state |
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The addition of water |
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The isolation of the ether |
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