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. How would the rapid accumulation of succinyl-CoA affect the rate of glucose oxidation?

. How would the rapid accumulation of succinyl-CoA affect the rate of glucose oxidation?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question 10

L Adipocytes store fat in phospholipid-coated droplets in the cytosol. The protein perilipin is also ossociated with the surface of the lipid droplet. (a) Describe the likely structure of the perilipin protein. (b) Explain how phosphorylation of perilipin could help expose the lipids in the droplet to digestion by lipases. 6 A deficiency of a citric acid cycle enzyme in both mitochondria and the cytosol of some tissues (e.g. blood lymphocytes) results in severe neurological abnormalities in newborns. The disease is herocterized by excretion in the urine of abnormally large amounts of a-ketoglutarate, succinate, and fumarate. What enzyme deficiency would lead to these symptoms? 7. Name the three enzymes that form the pyruvate dehydrogenase complex. 8 For each reaction listed below, indicate the appropriate enzyme(s) in the pyruvate dehydrogenase complex and the relevant cofactor(s), if applicable. 9. Reaction Enzyme Cofactor (a) Oxidative formation of an enzymatic disulfide bond (b) Transfer of hydroxyethyl group bound to TPP (c) Liberation of CO2 (d) Oxidation of dihydrolipoamide (e) Formation of acetyl-CoA 10. How would the rapid accumulation of succinyl-CoA affect the rate of glucose oxidation?
Transcribed Image Text:L Adipocytes store fat in phospholipid-coated droplets in the cytosol. The protein perilipin is also ossociated with the surface of the lipid droplet. (a) Describe the likely structure of the perilipin protein. (b) Explain how phosphorylation of perilipin could help expose the lipids in the droplet to digestion by lipases. 6 A deficiency of a citric acid cycle enzyme in both mitochondria and the cytosol of some tissues (e.g. blood lymphocytes) results in severe neurological abnormalities in newborns. The disease is herocterized by excretion in the urine of abnormally large amounts of a-ketoglutarate, succinate, and fumarate. What enzyme deficiency would lead to these symptoms? 7. Name the three enzymes that form the pyruvate dehydrogenase complex. 8 For each reaction listed below, indicate the appropriate enzyme(s) in the pyruvate dehydrogenase complex and the relevant cofactor(s), if applicable. 9. Reaction Enzyme Cofactor (a) Oxidative formation of an enzymatic disulfide bond (b) Transfer of hydroxyethyl group bound to TPP (c) Liberation of CO2 (d) Oxidation of dihydrolipoamide (e) Formation of acetyl-CoA 10. How would the rapid accumulation of succinyl-CoA affect the rate of glucose oxidation?
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