Answer all questions in complete sentences and paragraphs: 1. Explain the role of *H. pylori* in the pathogenesis of peptic ulcers. Which populations are most susceptible to peptic ulcers? Is *H. pylori* normal flora? If so, what causes the species to become pathogenic?

Helicobacter pylori requires 4 steps to colonize the host stomach: Survival in acidic environment…

Answered: . Explain the role of H. pylori in the…

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Answer all questions in complete sentences and paragraphs:

Expert Solution

Step 1

Helicobacter pylori requires 4 steps to colonize the host stomach:

Survival in acidic environment of stomach: here the bacteria neutralises acidic environment via urease activity
Using flagella to move towards epithelial cells
Using adhesins to attach to host cells: this is necessary for colonization and persistence of infection
Releasing toxin and hence causing tissue damage: example of some toxins release by helicobacter are Vacoulating cytotoxin A. In response chemokines are released by gastric epithelium that leads to gastritis and ulcer.