NURS5042 Tut 3

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Apr 3, 2024

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NURS5042: The Body, Its Function and Pharmacology School of Medical Sciences Tutorial 3 Cardiovascular complication Devised by: Dr Kyungjoon (Joon) Lim & Dr Elizabeth Cayanan Things to keep in mind during tutorials What has been altered from normal physiology (e.g. what is not working) Why is it not working (eg pathogenesis of the condition) What does the patient look like? (clinical manifestations)- and does this change over the time course of the condition (eg early to late stage changes per clinical condition of relevance. How should we manage the patient (as a nurse) ? After completing this workshop, you should be able to: - Extend from lecture - L02 explain pathogenic processes within the human body and their expression as observable alterations to normal anatomy/ physiological function across the life span - L03 synthesise, integrate and apply foundational human bioscience knowledge to specific contexts and situations in health - Extend from lecture - L04 locate and critically evaluate evidence-based drug information with respect to quality and relevance for informing decision making in nursing practice - Apply from lecture - L05 apply and integrate evidence-based pharmacotherapy knowledge to complex patients in order to optimise the quality use of medicines - L07 adopt an ethical, social and professional ethos in relation to the use of pharmacological therapies in health
After completing this workshop, you should be able to: - Have a firm understanding the following learning objectives related to Coronary Heart Disease, Hypertension and Myocardial Infarction. Coronary Heart Disease 1. Discuss the causes of coronary heart disease. 2. Discuss the pathogenesis of each of the following: 1. endothelial dysfunction 2. atherosclerosis 3. Heart Failure 3. Describe the pathogenesis and consequences of chronic ischaemic heart disease. 4. Discuss some of the factors which lead to cardiovascular disease. B. Hypertension and Myocardial infarction 1. Understand the classification(s) of hypertension. 2. Understand the meanings of primary, secondary, benign and malignant (accelerated) hypertension. 3. Discuss how and why hypertension causes pathological complications. 4. Describe the clinical effects that may occur following an acute myocardial infarction Extra resource: Utah Pathology Web Site Cardiovascular Disease: http://library.med.utah.edu/WebPath/CVHTML/CVIDX.html Images 1-41 only
Tutorial Activities Case 1: Hypertension Link to case study A 66-year-old woman was hospitalized for intense dyspnoea . She had a history of arterial hypertension and diabetes mellitus since the age of 56. Upon examination, she was in her regular general state, cyanotic , with a respiratory rate of 40 rpm, heart rate of 110 bpm and blood pressure of 140/100 mmHg and had oedema in lower limbs and lungs. She had a cardiac arrest and died. Autopsy revealed severe left ventricular hypertrophy. There was no evidence of coronary artery thrombosis or myocardial infarction . 1. What is the difference between benign/essential hypertension and malignant/severe hypertension? Primary Hypertension Secondary Hypertension Abnormally high blood pressure that's not caused by a medical condition. E.g. Obesity High blood pressure that's caused by another medical condition. E.g. Diabetes Malignant Hypertension (hypertensive crisis) Benign Hypertension (Hypertensive stage 1/2) Acute, severe and sudden onset. Anything above 120/80 Mild to moderate and progresses slowly but still needs medical attention. 140/90 -179/19 E.g. Atherosclerosis 2. What hypertension did this woman display, give reasons for your answer? Primary benign hypertension Type 2 diabetes at age 56 (related to lifestyle, not another disease) 3. What complications (others than those listed above) can arise from this type of hypertension? - Kidney, liver, spleen, heart failure any organ that passes blood which affects BP. - Thyroid problems - Obstructive sleep apnoea - Aneurism (swelling vessel) - Eye problems - Oedema - Thrombus (clots) - Embolus (Blood clot that moves in the vessels) 4. What was a likely cause of death in this woman and why? Left ventricle pumps blood out to the body. During left ventricular hypertrophy, the thickened heart wall can become stiff. Blood pressure in the heart increases. The changes make it harder for the heart to effectively pump blood. Eventually, the heart may fail to pump with as much force as needed. Decompensated heart failure When cells are under pressure, they change their size (hypertrophy), number (hyperplasia) and type (metaplasia) 5. On a separate note; what is “white coat” hypertension and how is it significant? White coat hypertension, a condition in which a patient's blood pressure readings are higher when taken at the doctor's office compared to other settings anxiety, stress Causes wrong readings, misdiagnoses
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Case 2: Hypertension Link to case study A 40-year-old female without a family history of hypertension presented with a sudden onset of hypertension (190/100 mmHg) and was referred to a nephrologist . She was moderately obese and smoked ten cigarettes per day. A renal angiogram demonstrated a partially narrowed left renal artery. 1. What type of hypertension did she have? Secondary (narrowed left renal artery requires medical treatment otherwise cannot go away), malignant 2. What is the most likely cause of renal artery stenosis? Obesity Build-up of fats, cholesterol and other substances (plaque) on kidney artery walls (atherosclerosis). 3. What caused the renal artery stenosis in this case ? Atherosclerosis – thickening of the artery wall 4. Starting with outline the development of hypertension in this case: Glossary : Increased blood pressure Reduced glomerular filtration rate (GFR) Secondary hypertension Reduced blood flow through kidney Conversion of angiotensin I to angiotensin II via angiotensin converting enzyme (ACE) in lungs 5. What complications could this hypertension cause? Hypertensive crisis. Same as previous question. Obstructed renal artery Reduced glomerular filtration rate (GFR) Reduced blood flow through kidney Conversion of angiotensinogen to angiotensin I (in blood) Increased renin secretion from kidney Conversion of angiotensin I to angiotensin II via angiotensin converting enzyme (ACE) in lungs Angiotensin II causes systemic arteriolar vasoconstriction Increased total peripheral resistance (TPR) Increased blood pressure Secondary hypertension hypertension
True/False with explanation; give reasons for your answer Where applicable give examples: HYPERTENSION, ISCHAEMIC HEART DISEASE AND MYOCARDIAL INFARCTION Hypertension is defined as blood pressure greater than 140/90mmHg TRUE. Hypertension is a risk factor for the development of atherosclerotic plaques. TRUE. Hypertension is usually caused by atherosclerosis. FALSE. Myocardial infarction (heart attack) is often caused by emboli. FALSE. Embolus (clot) are often formed in the periphery and developed in the arteries, flows through capillaries before reaching veins which are not large enough to block veins. Rupture of the heart wall would most likely occur within one week following a myocardial infarction. TRUE. Heart attacks cause necrosis which weaken the heart walls and cause ruptures. Arrhythmias are a common sequel of myocardial infarction. TRUE. Heart attacks cause irregular and erratic heartbeats. Increased pressure in the pulmonary artery causes hypertrophy of the left ventricle. FALSE. Pulmonary artery provides blood to the lungs from the right ventricle. Atrial fibrillation is a possible complication following an acute myocardial infarction. TRUE. Fibrillation = arrhythmia. Ventricular dilatation in chronic ischaemic heart disease is ultimately due to atrophy and stretching of the myocardium FALSE. Atrophy = cells get smaller. Not ultimately due to atrophy. Ventricles grow when pressure is increased. Ventricular fibrillation is not as life threatening as atrial fibrillation
FALSE. Both forms of arrhythmia and are life-threatening. Class Discussion or group based academic writing practice (with referencing) Note: In this section, students will practice using an academic writing style and present the findings at the end of the tutorial (or post it on the Ed Discussion forum, aiming for 400 words). This is to provide practice for assessment two with the opportunity for tutor feedback. Please use APA 7 th edition referencing style as per the assessment instructions. More resources on academic writing style can be found at the following link: https://www.sydney.edu.au/students/writing.html . We would recommend 3-4 references per section and would advise you avoid using general websites or blogs and seek peer reviewed sources primarily. You may choose to work individually or form a small group per condition. Answering the question will require you to look at evidence in class through a combination of MIMs, textbooks and journal articles. If time permits, small groups will be encouraged to produce a summary sheet per condition or a small class presentation to share their findings. Summary sheets can also be uploaded to the Ed discussion forum. Examples of conditions (not limited) in Cardiovascular disease a. Hypertension b. Coronary Heart Disease c. Hear Failure d. Myocardial infraction e. Stroke f. Congenital Heart Disease g. Pericardial disease Things to keep in mind when writing your answer: What has been altered from normal physiology (e.g. what is not working) Why is it not working (e.g. pathogenesis of the condition) What does the patient look like? (e.g.clinical manifestations) Does this change over the time course of the condition? (e.g. early to late stage changes per clinical condition of relevance. How can we manage the patient as a nurse ? Referencing guide: https://libguides.library.usyd.edu.au/citation/apa7 NOTE: Please avoid using websites and use journal articles or textbook material
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7 When producing academic writing, there are many approaches that can help. You may organise your facts into topics before presenting them in a considered paragraph. For example: Background and Introduction Condition X …. (is described as/ characterised by/ defined as) ….. (ref) It is commonly observed/seen/dignosed in … cohorts/patients of … (Age, sex, comorbid conditions/lifestyle factors /SDoH). Pathophysiology related to signs and symptoms in patient presentation The key pathophysiology underlying condition X is….. (ref). The clinical manifestations include …OR this leads to symptoms such as… OR this presents alongside changes in …or leads to further exacerbation of …. x,y and z (ref) (This would be a good opportunity to clearly explain why the symptoms are presenting in relation to the alteration in physiology)… Nurse Treatment or Management Common treatment for condition X is usually….. or involves a combination of ….. and …..(ref). Pharmacological management /non pharmacological options include X (ref) Common classes of medication used for condition X include ….( Different classes of drugs: Antibiotic/immune modulating/Steroid based) A registered nurse may be involved in the administration of …. X treatment and would be monitoring the patient using ….. parameters (Ref) with specific vigilance for …. complications or reactions….. (ref) The following excerpt is an example of academic writing style providing a summary of Pericardial Disease broadly in relation to background, pathophysiology, and assessment. Pericardial disease refers to a group of conditions that affect the pericardium, the sac surrounding the heart. These conditions can lead to various symptoms, including chest pain, shortness of breath, and heart failure. Nurses play a critical role in the identification, management, and education of patients with pericardial disease. One of the most common types of pericardial disease is acute pericarditis, which is characterized by inflammation of the pericardium. Patients with acute pericarditis often present with chest pain and may require treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids (Imazio et al., 2015). Pericardial effusion occurs when fluid accumulates in the pericardial sac, leading to compression of the heart. This can cause symptoms such as shortness of breath, fatigue, and chest pain. Treatment may include medication, drainage of the fluid, or surgery (Imazio et al., 2015). Constrictive pericarditis is a rare condition that occurs when the pericardium becomes thickened and stiff, leading to heart compression. Symptoms may include fatigue, swelling, and shortness of breath. Treatment often involves surgical removal of the pericardium (pericardiectomy) (Klein et al., 2021). Nurses play an essential role in the management of pericardial disease, including monitoring patients for signs and symptoms, administering medication, and providing education and support to patients and their families. They should also be knowledgeable about potential complications of pericardial disease, such as cardiac tamponade, and be prepared to intervene promptly (Imazio et al., 2015). Early diagnosis and treatment of pericardial disease can lead to improved outcomes for patients. Therefore, nurses should collaborate with other members of the healthcare team to ensure that patients receive timely and appropriate care. They can also provide emotional support to patients and their families, who may be anxious or distressed due to the diagnosis of a serious heart condition (Lampert et al., 2016). Respiratory Disease
8 In conclusion, pericardial disease is a complex condition that can have serious consequences if left untreated. Nurses play a critical role in the identification, management, and education of patients with pericardial disease. They should be familiar with the various types of pericardial disease, potential complications, and treatment options. By providing high-quality care and support, nurses can help improve outcomes for patients with pericardial disease. References: Imazio, M., Gaita, F., & LeWinter, M. (2015). Evaluation and treatment of pericarditis: a systematic review. JAMA, 314(14), 1498-1506. https://doi.org/10.1001/jama.2015.12763 Klein, A. L., Abbara, S., Agler, D. A., Appleton, C. P., Asher, C. R., Hoit, B., Hung, J., Garcia, M. J., Manning, W. J., Maslak, S., Oh, J. K., Ryan, T. J., Sachdeva, R., Shernan, S. K., Thavendiranathan, P., & Zoghbi, W. A. (2021). American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with pericardial disease: endorsed by the Society for Cardiovascular Magnetic Resonance and Society of Cardiovascular Computed Tomography. Journal of the American Society of Echocardiography, 34(8), 803-834. Respiratory Disease