Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Textbook Question
Chapter 35.4, Problem 1EQ
What was the purpose of the study conducted by Davis and colleagues?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 35 Solutions
Biology
Ch. 35.1 - Prob. 1CCCh. 35.3 - Core Skill: Connections Are fish a monophyletic...Ch. 35.3 - What features distinguish ray- finned fishes from...Ch. 35.3 - Prob. 2CCCh. 35.4 - What was the purpose of the study conducted by...Ch. 35.4 - Prob. 2EQCh. 35.4 - CoreSKILL Summarize the results of the...Ch. 35.4 - What were the advantages to animals of moving onto...Ch. 35.4 - Prob. 2CCCh. 35.5 - Prob. 1CC
Ch. 35.5 - Core Skill: Modeling The goal of this modeling...Ch. 35.5 - Prob. 2CCCh. 35.5 - Core Skill: Connections Look ahead to Figure...Ch. 35.5 - Prob. 3CCCh. 35.6 - Prob. 1CSCh. 35 - Which of the following is not a defining...Ch. 35 - Prob. 2TYCh. 35 - Prob. 3TYCh. 35 - Prob. 4TYCh. 35 - Prob. 5TYCh. 35 - Which clade does not include frogs? a. vertebrates...Ch. 35 - Prob. 7TYCh. 35 - Prob. 8TYCh. 35 - Prob. 9TYCh. 35 - Which of the following is not a distinguishing...Ch. 35 - Prob. 1CQCh. 35 - Prob. 2CQCh. 35 - Prob. 3CQCh. 35 - By what means can vertebrates move?Ch. 35 - Prob. 2COQ
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