To draw a mechanism for the six-membered condensation product obtained in reaction of 2,6-heptanedione with aqueous sodium hydroxide. Concept introduction: Aldol condensation reaction is where the aldol addition product undergoes dehydration to give a conjugated enone. In organic chemistry condensation reaction means loss of small molecules. For aldol condensation reaction to take place the starting material should have two α hydrogens in the same carbon atom. The driving force for aldol condensation reaction is the formation of conjugated system. The steps involved in aldol condensation reaction are, Deprotonation of α carbon Attach of enolate ion with the aldehyde ( nucleophilic attack ) Protonation of the alkoxide ion to give aldol product Dehydration of the aldol addition product to form conjugated enone (aldol condensation product) If the aldol condensation reaction takes place between two carbonyl compounds it is known as intermolecular aldol condensation reaction and if the same takes place within a single molecule means it is known as intramolecular aldol condensation reaction.

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Chapter 21.3, Problem 23CC

Interpretation Introduction

Interpretation:

To draw a mechanism for the six-membered condensation product obtained in reaction of 2,6-heptanedione with aqueous sodium hydroxide.

Concept introduction:

Aldol condensation reaction is where the aldol addition product undergoes dehydration to give a conjugated enone. In organic chemistry condensation reaction means loss of small molecules. For aldol condensation reaction to take place the starting material should have two α hydrogens in the same carbon atom. The driving force for aldol condensation reaction is the formation of conjugated system. The steps involved in aldol condensation reaction are,

Deprotonation of α carbon

Attach of enolate ion with the aldehyde (nucleophilic attack)

Protonation of the alkoxide ion to give aldol product

Dehydration of the aldol addition product to form conjugated enone (aldol condensation product)

If the aldol condensation reaction takes place between two carbonyl compounds it is known as intermolecular aldol condensation reaction and if the same takes place within a single molecule means it is known as intramolecular aldol condensation reaction.

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