Concept explainers
Propranolol is an antihypertensive agent—that is, it lowers blood pressure. (a)
Which proton in propranolol is most acidic? (b) What products are formed when propranolol is treated with

(a)
Interpretation: The most acidic proton in propranolol is to be identified.
Concept introduction: An acid is a substance that is capable to donate
Answer to Problem 36P
The most acidic proton is
Explanation of Solution
The given ball-and-stick model of propranolol is,
Figure 1
In ball-and-stick model, each colored ball represents a specific atom and each stick represents a bond. In this model, each black ball represents
Thus, the given compound is drawn as,
Figure 2
The acidity of an acid is directly proportional to the resonance stabilization of its conjugate base. In propranolol, when the
Figure 3
Thus, the most acidic proton is
The most acidic proton is

(b)
Interpretation: The products formed by the treatment of propranolol with
Concept introduction: Sodium hydride
Answer to Problem 36P
The product formed by the treatment of propranolol with
Explanation of Solution
Sodium hydride
The products formed by the treatment of propranolol with
Figure 4
The product formed by the treatment of propranolol with

(c)
Interpretation: The most basic atom in propranolol is to be identified.
Concept introduction: A base is a substance that is capable to accept a
Answer to Problem 36P
The most basic atom is
Explanation of Solution
A base is a substance that is capable to accept
Thus, the most basic atom is
The most basic atom is N of

(d)
Interpretation: The products formed by the treatment of propranolol with
Concept introduction: Hydrogen chloride
Answer to Problem 36P
The product formed by the treatment of propranolol with
Explanation of Solution
Hydrogen chloride
The product formed by the treatment of propranolol with
Figure 5
The product formed by the treatment of propranolol with
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Chapter 2 Solutions
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