CAMPBELL BIOLOGY-W/MOD.MASTERBIOLOGY
11th Edition
ISBN: 9780134683461
Author: Urry
Publisher: PEARSON
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Textbook Question
Chapter 11, Problem 11.2CR
How are the structures of a GPCR and an RTK similar? How does initiation of signal transduction differ for these two types of receptors?
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How are the structures of a GPCR and an RTK similar? How doesinitiation of signal transduction differ for these two types of receptors?
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a line of cultured cells has a highly active Gs linked system that leads to persistent activation of adenyl cyclase. which of the following treatments is most likely to decrease signaling through this pathway. A) overexpression of G-alpha protein , B) overexpression of phosphodieterase, C) overexpression of ras protein, D) treatment with GTP, E) treatment with a protein kinase C agonist
Chapter 11 Solutions
CAMPBELL BIOLOGY-W/MOD.MASTERBIOLOGY
Ch. 11.1 - Explain how signaling is involved in ensuring that...Ch. 11.1 - In liver cells, glycogen Phosphorylase acts in...Ch. 11.1 - Prob. 3CCCh. 11.2 - Nerve growth factor (NGF) is a water-soluble...Ch. 11.2 - WHAT IF? What would the effect be if a cell made...Ch. 11.2 - MAKE CONNECTIONS How is ligand binding similar to...Ch. 11.3 - What is a protein kinase, and what is its role in...Ch. 11.3 - When a signal transduction pathway involves a...Ch. 11.3 - What is the actual signal that is being transduced...Ch. 11.3 - WHAT IF? If you exposed a cell to a ligand that...
Ch. 11.4 - How can a targct cell's response to a single...Ch. 11.4 - WHAT IF? If two cells have different scaffolding...Ch. 11.4 - Prob. 3CCCh. 11.5 - Give an example of apoptosis during embryonic...Ch. 11.5 - WH AT IF? If apoptosis occurred when it should...Ch. 11 - What determines whether a cell responds to a...Ch. 11 - How are the structures of a GPCR and an RTK...Ch. 11 - What is the difference between a protein kinase...Ch. 11 - What mechanisms in the cell terminale its response...Ch. 11 - What is an explanation for the similarities...Ch. 11 - Binding of a signaling molecule to which type of...Ch. 11 - The activation of receptor tyrosinc kinases is...Ch. 11 - Lipid-soluble signaling molecules, such as...Ch. 11 - Consider this pathway: epinephrine G...Ch. 11 - Apoptosis involves all but which of the following?...Ch. 11 - Which Observation suggestcd to Sutherland the...Ch. 11 - Protein phosphorylation is commonly involved with...Ch. 11 - DRAW IT Draw the following apoptotic pathway,...Ch. 11 - EVOLUTION CONNECTION Identify the evolutlonary...Ch. 11 - Prob. 10TYUCh. 11 - SCIENCE, TECHNOLOGY, AND SOCIETY The aging process...Ch. 11 - WRITE ABOUT A THEME: ORGANIZATION The properties...Ch. 11 - SYNTHESIZE YOUR KNOWLEDGE There are five basic...
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- Compare and contrast GPCR and RTK receptors with respect to (a)structure (especially the transmembrane region), (b) activation mechanism, and (c) initial signal transduction across the membrane.arrow_forwardWhat do the cytoplasmic domain of a G protein-coupled receptor and the adaptor protein in the RTK pathway have in common?arrow_forwardWhat is the largest family of cell surface receptors (>1% of the human genome)?arrow_forward
- In which of the following signaling pathways does ligand binding induce the phosphorylation of the receptor molecules? (Check all that apply.) A The TGF-beta pathway. B The Hedgehog/smoothened pathway. The Notch/Delta pathway. D) The Receptor-tyrosine kinase pathway. E) The canonical Wnt pathway.arrow_forwardWhat is signal transduction? Illustrate and describe the molecular events in signal transduction pathways involving 1) G-protein-coupled receptors and 2) enzyme linked receptors.arrow_forwardHow is down-regulation possible in regulation receptors?arrow_forward
- My boss has given me the purified extracellular portion of the Notch receptor. As Delta/Notch signaling occurs between cells, I know that both the Notch receptor and and Delta are most likely "comfortable" in the environment of the blood, not the cytosol, nucleus, mitochondria, etc... I want to purify Delta, the signal. What would be true of the most specific purification technique I could choose, i.e. the technique that will result in the fewest proteins in the fraction containing Delta? Do not worry about whether the protein works after fractionation yet. Pick ALL that apply. I would use ion exchange chromatography. I would use size exclusion chromatography I would use affinity chromatography I would use a water based mobile phase of 7.4 I would use an acetonitrile mobile phase with a pH of 7.4 I would use a water based mobile phase of pH 7.2 I would use an acetonitrile phase of 7.2 I…arrow_forwardWhat type of signal transduction molecule does the DAMGO receptor couple to?arrow_forwardIf a cell expresses a dominant-negative tyrosine-kinase-linked receptor (RTK) that lacks the kinase domain, which of the following will still happen in response to a growth factor that binds the RTK? A Receptor cross-phosphorylation. Activation of target proteins by Ras. C) Receptor dimerization. D) Binding of the growth factor to its receptor. Interaction of Ras with the activated receptor. Barrow_forward
- What is the JAK family responsible for? What types of signaling happens within these types of receptors?arrow_forwardWe saw that GPCRs have a basal level of constitutive activity. Not all receptors do. Why might having this constitutive activity be a benefit to the cells?arrow_forwardDifferent cell types express different types of receptors; even asingle cell may express multiple receptor types. Explain?arrow_forward
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