Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781260163698
Author: Cowan
Publisher: MCG
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Chapter 10, Problem 8Q
Conduct research to find out why drugs blocking folic acid synthesis are highly selective (not harmful to humans).
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Which of the following enzymes is involved in the oxidation reaction (drug metabolism)?
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Chapter 10 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 10.1 - State the main goal of antimicrobial treatment.Ch. 10.1 - Identify the sources for the most commonly used...Ch. 10.1 - Describe two methods for testing antimicrobial...Ch. 10.1 - Prob. 4AYPCh. 10.1 - NCLEX PREP 1. An RN is caring for a 26-year-old...Ch. 10.2 - Explain the concept of selective toxicity.Ch. 10.2 - List the five major targets of antimicrobial...Ch. 10.2 - Prob. 7AYPCh. 10.2 - Distinguish between broad-spectrum and...Ch. 10.2 - Prob. 9AYP
Ch. 10.2 - Explain the mode of action of penicillinases and...Ch. 10.2 - Identify two antimicrobials that act by inhibiting...Ch. 10.2 - Prob. 12AYPCh. 10.2 - Identify one example of a fluoroquinolone.Ch. 10.2 - Describe the mode of action of drugs that target...Ch. 10.2 - Prob. 15AYPCh. 10.2 - Prob. 16AYPCh. 10.2 - Explain why antiprotozoal and antihelminthic drugs...Ch. 10.2 - List the three major targets of action of...Ch. 10.2 - Prob. 2NPCh. 10.3 - Discuss two main ways that microbes acquire...Ch. 10.3 - List five cellular or structural mechanisms that...Ch. 10.3 - Prob. 21AYPCh. 10.3 - Prob. 3NPCh. 10.3 - Prob. 1MMCh. 10.4 - Distinguish between drug toxicity and allergic...Ch. 10.4 - Prob. 23AYPCh. 10.4 - Prob. 4NPCh. 10.4 - Prob. 5NPCh. 10 - Microbial resistance to drugs is acquired through...Ch. 10 - Prob. 2QCh. 10 - Prob. 3QCh. 10 - Prob. 4QCh. 10 - Why does the penicillin group of antibiotics have...Ch. 10 - Prob. 6QCh. 10 - Prob. 7QCh. 10 - Conduct research to find out why drugs blocking...Ch. 10 - Prob. 9QCh. 10 - Prob. 10QCh. 10 - You take a sample from a growth-free portion of...Ch. 10 - Prob. 12QCh. 10 - Treating malarial infections is theoretically...Ch. 10 - Can you think of a situation in which it would be...Ch. 10 - Prob. 15QCh. 10 - Prob. 16QCh. 10 - Prob. 17QCh. 10 - Prob. 18QCh. 10 - An antimicrobial drug with a _______ therapeutic...Ch. 10 - Prob. 20QCh. 10 - Prob. 21QCh. 10 - Prob. 1VC
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- A substance acted upon and changed by anenzyme is called the enzyme’sarrow_forwardCan you please help me answer the following questions. An enzymatic pathway is organized so that the final product will act as a competitive inhibitor to the first enzyme in the pathway. This is an example of: A. denaturation of a substrate enzyme complex B. positive feedback inhibition C. negative feedback inhibition D. competive binding of a productarrow_forwardPenicillinase ( β-lactamase) hydrolyzes penicillin. Compare penicillinase with glycopeptide transpeptidase.arrow_forward
- Name the three basic classes of drug targets in medicinal chemistry and indicate, which are the most/least important as targets for biologics? I don't sure if I answer these questions correctly. Hope someone can give me confirmation and explain to me how enzymes will be affected by bioloigcs? My answer so far: The three common classes of drug targets are; receptors, nucleic acid, and enzymes. As a target for biologics, the least important will be a nucleic acid, and the most important will be receptor and second enzymes. Biologic drugs such as monoclonal antibodies will bind to the antigens, which are overexpressed receptor that need to be deactivated. In this case, the monoclonal antibodies will act as an antagonist and block the ligand from binding to the antigens, which are extensively presented in cancer cells. In addition, it can also affect enzymes by.......?arrow_forwardWhich of the following enzymes is involved in the oxidation reaction (drug metabolism)? Select one: Lactate dehydrogenase Esterase Cytochrome P450 Chymotrypsinarrow_forwardInhibitors are common in biological systems. Why might some organisms release enzyme inhibitors into their surrounding environment?arrow_forward
- Concept MapTry putting the words in bold font in the "explain section (pages 13-14) into perspective. Relate all the said words you have read in the "explain" section altogether by doing a concept map.arrow_forwardAn acidic environment is inhibitory to decarboxylase activity. True Falsearrow_forwardWhat mechanism of action does Ciprofloxacin belong in? 1.inhibition of cell wall synthesis 2.inhibition of nucleic acid synthesis 3.inhibition of metabolic pathway 4.inhibition of protein synthesisarrow_forward
- Two different methods are described in the literature to portray the pharmacokinetics of ethanol. The Widmark method would likely be used by which of the following? oxicologists Pharmacists Pharmacologist none of the abovearrow_forwardProteases are one of the main drug targets. Choose the False statement regarding proteases. A. Proteases are enzymes that cleave peptide bonds. B. Water is a reactant in the reaction catalyzed by proteases. C. Proteases, like all enzymes show substrate specificity, meaning they cleave only substate that fit the bonding product. D. Proteases rely on the proton transfer from NADH to the substrate. E. Protease mechanism involves only acid-base catalysis.arrow_forwardWhich of the following enzymes requires a cofactor to carry out catalysis? A- GI lipase B- HIV protease C- Aldehyde dehydrogenase D- Epoxide hydrolase E- Beta-Lactamasearrow_forward
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