Saccharide M, a sugar made of repeating units of maltose and cellobiose, is a componentof glycoproteins 1 and 2, which are receptors found in the membrane of Shrek's cells. For glycoprotein1, saccharide M is attached by an a 1® 2 linkages to 3 sialic acid residues, then O-linked to the protein,while glycoprotein 2 has saccharide M attached by a b 1®3 bond also to 3 sialic acid residues, then it isalso O-linked to the protein. Glycoprotein 1 is a transporter protein for glucose, while glycoprotein 2 is theNa*-K*receptor/ transporter. The glycoproteins show 99% sequence homology of its amino acid sequence.a. Explain briefly why there is a difference in the functions of glycoprotein 1 and 2b. Glycoprotein 1 is a receptor for glucose. Using Benedict's reagent, tests on the glycoprotein gaveNEGATIVE results. Give 2 amino acids that can O-link with Saccharide M and show the portion of bothprotein and saccharide where a bond will be formed.

Glycoproteins are consisted of protein and glycan moiety which is involved in several biological…

Answered: Saccharide M, a sugar made of repeating…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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A heptapeptide was found to have an amino acid composition of Asp, Leu, Lys, 2 Met, Phe and Tyr. (a) Trypsin has no effect on the heptapeptide. (b) The phenyl thiohydantoin released by Edman degradation revealed phenylalanine in the N-terminus. (c) Brief chymotrypsin treatment yielded several products including a dipeptide and a tetrapeptide. The amino acid composition of the tetrapeptide was Leu, Lys, and Met. (d) Cyanogen bromide treatment yielded a dipeptide, a tetrapeptide, and free Lys. What is the amino acid sequence of this heptapeptide? Answer Format: (Three letter abbreviation with dash ie., Ala-Gly-…) *
c) A lysine residue in the active site of UstD is involved in forming a covalent Schiff base linkage with the PLP cofactor. In order for this linkage to form, the lysine residue must be in its deprotonated form. Draw the structure of the R group of lysine in this neutral form. What is the ratio of the concentration of this form to that of its conjugate acid form at neutral pH? ( )
In the laboratory a team of peptide/protein chemists synthesize the HIV-1 protease from all D-containing amino acids. Answer the following questions related to this synthetic HIV-1 protease. The HIV-1 protease would DA cut polypeptides with a certain sequence if they are made of D-amino acids. OR assume a tertiary structure that is the mirror image of the normal HIV-1 protease. nc cut polypeptides with a certain sequence if they are made of L-amino acids. OD process the proteins expressed on infection by the natural HIV-1 pathogen. DE behave exactly like the normal HIV-1 protease. tinn will save this response. Question 34 of 55
PfCRT is found to have 10 peaks on a hydropathy plot given its primary sequence. Researchers also noted that each peak is comprised of about 30 amino acids. The digestive vacuole membrane is 45Å in Plasmodium species. Explain why researchers conclude there are 10 transmembrane helices from these two pieces of data.
is it true that aplha and beta are made up of same amino acids but Beta chain is longer than alpha chain？what is other difference and similarity？is the amino aicd sequence exactly the same as well？are their structure the same ？
Consider the peptide Asp-Lys-Phe-Glu-Asn-Tyr-Gln-Val-Cys. In a single beaker, you treat this peptide with 2 proteases. One protease cleaves at the N-terminus of aromatic R groups and the other cleaves at the C-terminus of polar, non-ionizable R groups. Following the enzymatic digestion, you want to separate your peptide fragments so that you can identify them. You choose to separate the fragments using an anion exchange column. Beginning at pH=6 you apply your peptide fragments to the column and you gradually decrease the pH of the column stopping the separation when the pH of the column equals 4. Omitting chemical structures, write the amino acid sequence of the peptide fragments that are produced from this digest. Write the order that these fragments will elute from the column (if at all). (Relevant pKa values are: 2.1, 3.8, 4.3, 8.3, 9.6, 10.1, and 10.5)
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What is the fraction of the peptide that has the N-terminal amino group deprotonated at pH 9. Please show your answer as a percent of deprotonated N-terminal species relative to all (protonated and deprotonated) N-terminal species. Can you show your calculations so I can understand your method of approach?
How does NH4SO4 affect water structure? What does this have to do with protein solubility? I thought the answer was that NH4S04 attracts H2O so the protein doesn't bind to H2O allowing the protein to bind to each other. But the answer given is, orders water locally to become more ice-like. Can someone explain?
Most animals cannot use wool for nourishment. An exception is the clothes moth: it can derive nourishment from eating clothing made of natural fibers such as wool (which is rich in a-keratin). The digestive tract of the larvae of clothes moths provides a highly reducing environment. Why is this beneficial to the larvae? The reducing environment will reduce the disulfide linkages, making it easier to digest the proteins. The reducing environment will hydrolyze the peptide bonds. The reducing environment will interfere with the H-bonding between the tropocollagen molecules, making the type of protein found in most natural fibres easier to digest. The reducing environment will help to kill bacterial pathogens. The reducing environment will detoxify the carcinogenic dyes used in the textile industry.
Given the peptide Val-Ser-Gln-Lys The lateral chain of one of these amino acids can be modified by N-acetylation. Write the semi‐developed form of the lateral chain of this modified amino acid at pH 7 The lateral chain of one of these amino acids can be modified by phosphorylation. Write the semi‐developed form of the lateral chain of this modified amino acid at pH 7.
The melanocyte-stimulating hormone a-melanotropin has the following sequence: Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val In the one-letter code of amino acids, this sequence would be: SYSMEHFRWGKPV STSMGHFAWGKPV O SYSMDHFAWGKPV O SYSMEHFAWGLPV

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