IL-6 is a cytokine released as an immune response to infection. Elevated IL-6 is suggested to be predictive of severe illness with Covid-19. Suppose we wanted to conduct a study to see if this is true among patients with Covid-19 in Florida. Assuming from a previous studies in other areas of the US, the mean IL-6 id 11.48 pg/mL (s.d. 10.84 pg/mL) among individuals with moderate disease and 7.66 pg/mL (s.d.= 4.52 pg/mL) among individuals that are asymptomatic or have mild illness, how many people ,in total, would need to enroll in our new study to determine if there is a difference in means with 99% confidence and 80% power? A. 48 В. 31 C. 58 D. 69

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