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hospital, his physician told him that his infarction is the result of a long history of smoking. Explain the conclusion of the specialist. For that: a) explain the functions of lipoproteins in cholesterol transport using the schemes;

hospital, his physician told him that his infarction is the result of a long history of smoking. Explain the conclusion of the specialist. For that: a) explain the functions of lipoproteins in cholesterol transport using the schemes;

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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6. A 60-year-old man has been smoking since his 30s. After a heated argument with his colleagues in office he experienced an acute pain across his chest, associated with shortness of breath, a sense of light-headedness and sweating. He was rushed to the hospital emergency department, where his clectrocardiogram showed changes consistent with an acute infarction. Blood was sent to the laboratory for biochemical tests, including the total cholesterol, LDL cholesterol and HDL cholesterol. The blood lipid levels (in mg/dL) were: TAG – 290, total cholesterol - 325, LDL cholesterol – 245, HDL cholesterol - 25. The patient was treated intensively and got better. Before he was discharged from the 7.13. Hypercholesterolemia. Biochemical Aspects of Atherosclerosis. Cholesterol-Lowering Agents 393 hospital, his physician told him that his infarction is the result of a long history of smoking. Explain the conclusion of the specialist. For that: a) explain the functions of lipoproteins in cholesterol transport using the schemes; b) describe the structure of LDL receptor, regulation of its synthesis in the liver and function in cholesterol metabolism; c) name all possible causes of the hypercholesterolemia; d) explain the mechanism of prolonged smoking on the hypercholesterolemia and atherosclerosis development.
Transcribed Image Text:6. A 60-year-old man has been smoking since his 30s. After a heated argument with his colleagues in office he experienced an acute pain across his chest, associated with shortness of breath, a sense of light-headedness and sweating. He was rushed to the hospital emergency department, where his clectrocardiogram showed changes consistent with an acute infarction. Blood was sent to the laboratory for biochemical tests, including the total cholesterol, LDL cholesterol and HDL cholesterol. The blood lipid levels (in mg/dL) were: TAG – 290, total cholesterol - 325, LDL cholesterol – 245, HDL cholesterol - 25. The patient was treated intensively and got better. Before he was discharged from the 7.13. Hypercholesterolemia. Biochemical Aspects of Atherosclerosis. Cholesterol-Lowering Agents 393 hospital, his physician told him that his infarction is the result of a long history of smoking. Explain the conclusion of the specialist. For that: a) explain the functions of lipoproteins in cholesterol transport using the schemes; b) describe the structure of LDL receptor, regulation of its synthesis in the liver and function in cholesterol metabolism; c) name all possible causes of the hypercholesterolemia; d) explain the mechanism of prolonged smoking on the hypercholesterolemia and atherosclerosis development.
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