Gly-Pro-Glu (Glypromate) is a neuroprotective compound originally developed at the University Auckland. After showing promise for the treatment of neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's diseases the compound was passed to Neuren Pharmaceuticals who began development of the drug in collaboration with Pfizer. Glypromate Design a solid-phase synthesis of the tripeptide Gly-Pro-Glu, using Fmoc-protected amino acids. Ensure to include all synthetic steps (resin loading, protection, coupling, deprotection) and sugges

Gly-Pro-Glu (Glypromate) is a neuroprotective compound originally developed at the University Auckland. After showing promise for the treatment of neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's diseases the compound was passed to Neuren Pharmaceuticals who began development of the drug in collaboration with Pfizer. Glypromate Design a solid-phase synthesis of the tripeptide Gly-Pro-Glu, using Fmoc-protected amino acids. Ensure to include all synthetic steps (resin loading, protection, coupling, deprotection) and sugges

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Subject-chemistry
Another method to form a peptide bond involves a two-step process Reaction of the p-nitrophenyl ester with an amino acid ester. Why does a p-nitrophenyl ester “activate” the carboxy group of thefirst amino acid to amide formation?
Chemistry Reduced glutathione (GSH) is used to Select one a.maintain amino acid transport across cell membranes b.maintain lipid peroxidation while GSH itself is convened to oxidized glutathione (GSSG) c.maintain high level of NADPH in the cell d.reduce disulfide bonds and lipid peroxides back to their original native states while GSH is to ( GSSG)
A portion of sphingomyelin is shown below. Select the most accurate description of R1, R2, and R3 from the choices below the structure: R1 он NH R2 R3 A: R1 is the hydrocarbon tail of sphingosine; R2 is from a fatty acid; R3 is a tertiary amine B: R1 is from a fatty acid; R2 is from a fatty acid, R3 is a quaternary amine C: R1 is from a fatty acid; R2 is the hydrocarbon chain of sphingosine, R3 is a tertiary amine D: R1 is from a fatty acid; R2 is the hydrocarbon chain of sphingosine, R3 is a quaternary amine
Ethyleneimine reacts with cysteine side chains in proteins to form S - aminoethyl derivatives. The peptide bonds on the carboxyl side of these modified cysteine residues are susceptible to hydrolysis by trypsin . Why?
Please explain the answer in details
a) Propose a synthesis using a maximum number of 5 synthetic steps, for the dipeptide NH2-ILE-ASP-COOH. Explain your choice of protecting groups
A decapeptide has the following amino acid composition:Ala2 , Arg, Cys, Glu, Gly, Leu, Lys, Phe, ValPartial hydrolysis yields the following tripeptides:Cys-Glu-Leu + Gly-Arg-Cys + Leu-Ala-Ala+ Lys-Val-Phe + Val-Phe-Gly.Reaction of the decapeptide with 2,4-dinitrofluorobenzene yields 2,4-dinitrophenylysine. Fromthe experimental data, suggest a scheme you will follow to synthesize the dipeptide Ala-Gly
What is the product of the starting material D-glyceraldehyde which will (1) produce aldaric acid upon reacting with HNO3 + H2O, NaOCH2, NH2OH, and (CH3CO)2O + NaOCOCH3 (2) produce tartaric acid upon reacting with HNO3 + H2O, NaOCH3, NH2OH, and (CH3CO)2O + NaOCOCH3
1. Write the equation of the reaction of oxidative deamination of alanine (in vitro). Specify the conditions of its passage. Name the reaction product. 2. Which of the following formulas of aspartic acid will prevail at pH = 12? Write the equation of dissociation of this acid. HOOC-CH2-CH-COO HOOC-CH2-CH-COOH *NH3 *NH3 1) HOOC-CH2-CH-COO OOC-CH₂-CH-COO™ NH₂ NH₂ 3) 2)
A biochemist completely digests a glycerophospholipid with a mixture of phospholipases A and D. HPLC and mass spectrometry analysis reveals the presence of an amino acid of 105,09 Da, a saturated fatty acid of 256.43 Da, and an omega-3 monounsaturated fatty acid of 282.45 Da. Which amino acid does the glycerophospholipid contain? O valine (C,H, NO,) O alanine (C, H,NO,) O scrine (C,H,NO,) O proline (C,H,NO,) Modify the phosphoglycerol backbone to draw the most likely structure of the lipid. Add the amino acid using the groups tool. Draw Rings Groups More Erase Select