Cp(mg/L) 25 20- 15- 10- 5- 2 A 10 Cp(mg/L) 25- 20- 15- 10- 5- 2 B 10 Time (h) Time (h) Comparison of kaurenoic acid plasma decay (dose = 50 mg/kg). (A) Intravenous route. (B) Oral route.
Cp(mg/L) 25 20- 15- 10- 5- 2 A 10 Cp(mg/L) 25- 20- 15- 10- 5- 2 B 10 Time (h) Time (h) Comparison of kaurenoic acid plasma decay (dose = 50 mg/kg). (A) Intravenous route. (B) Oral route.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Kaurenoic acid is an active ingredient found in
various plants, including stevia.
Scientists investigated the pharmacokinetic profile
of 50 mg/kg of kaurenoic acid in rats after
intravenous (IV) vs oral administration. The plots
below were obtained.
Cp(mg/L)
25
20-
15-
10-
0
2
•
4
A
8
Cp(mg/L)
10
25-
20-
15-
6
6
Time (h)
Time (h)
Comparison of kaurenoic acid plasma decay (dose = 50 mg/kg). (A) Intravenous route. (B) Oral route.
10-
5-
0+
0
4
B
8
10
The IV plot could be fitted by the equation:
Cp = 28 exp(-1.2t) - where Cp (mg/L) is the plasma
concentration and t (h) the time after administration
of a 50 mg/kg single dose.
Transcribed Image Text:1) Briefly discuss whether kaurenoic acid activity is
to be expected from commercial 150 mg stevia
capsules.
2) From the IV results, determine the parameters
listed below. Provide the final formula used and
correct units.
- Apparent volume of distribution (per kg of body
weight);
- Half-life;
- Clearance (per kg of body weight).
3) Briefly discuss whether the parameters you
calculated apply to both routes of administration
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