Carbamoyl-phosphate synthase I is a mitochondrial enzyme which plays an important role inthe urea cycle. It represents the committed step in the urea cycle.(i)Explain the reaction of carbamoyl-phosphate synthase I.(ii)Explain the regulation of urea cycle by N-acetylglutamate.

The urea cycle begins inside the mitochondria of hepatocytes but three of the steps occur in the…

Answered: byl-phosphate synthase I is a…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

See similar textbooks

Similar questions

The symptoms of partial deficiency of a urea cycle enzyme may be minimized by a low- protein diet. Explain.
Discuss the two roles of N-acetylglutamate in the urea cycle. Include relevant chemical structures and reactions. What is the regulatory function of N-acetylglutamate in the urea cycle? What is the other role of N-acetylglutamate in relationship to the urea cycle? Glutamate is the precursor for N-acetylglutamate. How is glutamate involved in the connection between the urea cycle and the CAC?
Lactate dehydrogenase is a tetramer of MW 134000 g/mole composed of subunits which are equal in size. It is found in the cytoplasm of eukaryotic and prokaryotic cells. Describe the secondary, tertiary and quaternary structures of lactate dehydrogenase.
Why is phenylketonuria resulting from dihydropteridine reductase deficiency a more serious disorder than PKU resulting from phenylalaninehydroxylase deficiency?
Glutamate, produced in the first transamination reaction, reacts with oxaloacetate in the second transamination reaction to form aspartate that can directly enter the urea cycle. In an oxidative deamination reaction, the same glutamate molecule, through the action of glutamate dehydrogenase along with the presence of the coenzyme NAD+, can produce an ammonium ion which can also directly enter the urea cycle. The first statement is incorrect while the second statement is correct The first statement is correct while the second statement is incorrect Both statements are correct Both statements are incorrect
When transaminated, the three branched-chain amino acids (valine, leucine, and isoleucine) form compounds that have the characteristic odor of maple syrup. An enzyme known as branched-chain a-keto acid dehydrogenase converts these compounds into CoA esters. People who do not have this enzyme have the genetic disease known as maple syrup urine disease, so called because their urine smells like maple syrup. a. Draw the compounds that smell like maple syrup.b. Draw the CoA esters.c. Branched-chain a-keto acid dehydrogenase has five coenzymes. Identify them.d. Suggest a way to treat maple syrup urine disease.
Write an equation for the net reaction of the urea cycle.Show how the urea cycle is linked to the citric acid cycle.
Explain the reasons for the oxidation of acetate through complex pathways in the citrate cycle.
The urea cycle can be summarized through the following reaction: O || H2N-C-OPO3 + COO- | H3N-CHCH₂COO b. O || H2N-C-NH2 1a Write the reactions, using structural formulas that lead to the formation of carbamoyl phosphate and its subsequent incorporation into the urea cycle. Name the enzymes and how they are activated. 1 + OOCCH=CHCOO- Write the rest of the reactions that constitute the urea cycle using structural formulas. Name the enzymes that catalyze each reaction. Indicate which reactions occur in the mitochondrion and which occur in the cytoplasm.
Malate dehydrogenase has a ΔGo′ΔGo′= 29.5 kJ/mol for the formation of oxaloacetate from malate yet plays a crucial role in the Citric Acid Cycle. Explain (briefly) how this enzyme with a very non-spontaneous ΔGo′ΔGo′can function well in a biochemical pathway.
Identify urea in the Urea cycle below and show/explain where the two Nitrogen atoms of urea originate from. 3 2 ATP + HCO3 + NH3 4 CPS-1 2 ADP, P₁ NH3 CH₂ CH₂ CH₂ HC-NH3 Coo 1 7 H₂N NH₂ H₂N O=UN ARG1 H₂O OPO3²- feeli. NH₂ CH₂ CH₂ OTC CH₂ P₁ HỘ—NH3* ·8-3-4-8 • ASL CH 5 ΝΗ CH₂ CH₂ CH₂ HỘNH3 COO NH₂ 3 3 ASS NH COO ΝΗ CH₂ CH₂ COO- CH₂ CH₂ HỘ NH3* COO 4 ATP PP₁ L-Asp AMP
Which amino acids in the urea cycle are the links to thecitric acid cycle? Show how these links occur

SEE MORE QUESTIONS

Recommended textbooks for you

Human Anatomy & Physiology (11th Edition)

Biology

ISBN:

9780134580999

Author:

Elaine N. Marieb, Katja N. Hoehn

Publisher:

PEARSON

Biology 2e

Biology

ISBN:

9781947172517

Author:

Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:

OpenStax

Anatomy & Physiology

Biology

ISBN:

9781259398629

Author:

McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter

Publisher:

Mcgraw Hill Education,

Human Anatomy & Physiology (11th Edition)

Biology

ISBN:

9780134580999

Author:

Elaine N. Marieb, Katja N. Hoehn

Publisher:

PEARSON

Biology 2e

Biology

ISBN:

9781947172517

Author:

Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:

OpenStax

Anatomy & Physiology

Biology

ISBN:

9781259398629

Author:

McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter

Publisher:

Mcgraw Hill Education,

Molecular Biology of the Cell (Sixth Edition)

Biology

ISBN:

9780815344322

Author:

Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter

Publisher:

W. W. Norton & Company

Laboratory Manual For Human Anatomy & Physiology

Biology

ISBN:

9781260159363

Author:

Martin, Terry R., Prentice-craver, Cynthia

Publisher:

McGraw-Hill Publishing Co.

Inquiry Into Life (16th Edition)

Biology

ISBN:

9781260231700

Author:

Sylvia S. Mader, Michael Windelspecht

Publisher:

McGraw Hill Education

SEE MORE TEXTBOOKS

byl-phosphate synthase I is a mitochondrial enzyme which plays an important role in cycle. It represents the committed step in the urea cycle. Explain the reaction of carbamoyl-phosphate synthase I. Explain the regulation of urea cycle by N-acetylglutamate.