7. If you have aligned orthologous gene sequences from an important, conserved gene; there is a different way you can determine reading frame. a. The following sequences of orthologous copies of the insulin receptor gene (INSR) from four species. The sequences are aligned but the reading frame is unknown. What is the reading frame for these sequences? (ie., Does the first complete codon begin at the first, second, or third nucleotide?) Hint: Think about what you know about the nature of mutations, natural selection and the genetic code. 1. Bear CCTGAAGAGCTACCTCCG CTCCCTG C G G C C G GAGGCTGAGAATAACCCC GG CCGCCCT CCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTG GCC G C CCT 2. Human 3. Chicken 4. Cow CTTGAAAAGCTACCTACGCTCTCTGAGACCCGACGCTGAGAATAACCCTGGTCGTCCA CCTGAAGAGTTACCTCCGTTCCCTG C G G CCT GAGGCTGAGAATAACCCCG GCC GCCCT

Human Anatomy & Physiology (11th Edition)
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7. If you have aligned orthologous gene sequences from an important, conserved gene; there is a different
way you can determine reading frame.
a. The following sequences of orthologous copies of the insulin receptor gene (INSR) from four species.
The sequences are aligned but the reading frame is unknown. What is the reading frame for these
sequences? (ie., Does the first complete codon begin at the first, second, or third nucleotide?) Hint:
Think about what you know about the nature of mutations, natural selection and the genetic
code.
1. Bear
CCTGAAGAGCTACCICCGCICCCIGCGGCCGGAGGCTGAGAATAACCCCGGCCGCCCT
2. Human
CCTGAAGAGCTACCICCGTICICIGCGGCCAGAGGCTGAGAATAATCCIGGCCGCCCI
3. Chicken CITGAAAAGCTACCIACGCTCICIGAGACCCGACGCIGAGAATAACCCTGGICGICCA
4. Cow
CCTGAAGAGTTACCTCCGTTCCCIGCGGCCTGAGGCTGAGAATAACCCCGGCCGCCCT
Answer:
Transcribed Image Text:7. If you have aligned orthologous gene sequences from an important, conserved gene; there is a different way you can determine reading frame. a. The following sequences of orthologous copies of the insulin receptor gene (INSR) from four species. The sequences are aligned but the reading frame is unknown. What is the reading frame for these sequences? (ie., Does the first complete codon begin at the first, second, or third nucleotide?) Hint: Think about what you know about the nature of mutations, natural selection and the genetic code. 1. Bear CCTGAAGAGCTACCICCGCICCCIGCGGCCGGAGGCTGAGAATAACCCCGGCCGCCCT 2. Human CCTGAAGAGCTACCICCGTICICIGCGGCCAGAGGCTGAGAATAATCCIGGCCGCCCI 3. Chicken CITGAAAAGCTACCIACGCTCICIGAGACCCGACGCIGAGAATAACCCTGGICGICCA 4. Cow CCTGAAGAGTTACCTCCGTTCCCIGCGGCCTGAGGCTGAGAATAACCCCGGCCGCCCT Answer:
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