3. General Knowledge Rank the following compounds using numbers 1-4 in the box provided. (1 = most, 4 = least) a. SN2 reactivity with NaOme Br Br b. SN1 reactivity with HBr НО OH c. E2 reactivity with KO'Bu Br. Br Br Br d. Consider the following secondary halides. Changing the leaving group from fluoride to bromide would increase the rate of which of the following mechanisms? Circle all that apply. F Br SN1 SN2 E1 E2 OH NH₂ OH

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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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# General Knowledge

### Rank the following compounds using numbers 1-4 in the box provided (1 = most, 4 = least)

#### a. \( S_N2 \) reactivity with \( NaOMe \)

Below are four organic compounds. You should rank their reactivity towards \( S_N2 \) mechanisms when reacted with sodium methoxide (NaOMe). 

From left to right:
1. Compound with a bromo group attached to a linear alkyl chain
2. Compound with an iodo group attached to a linear alkyl chain
3. Compound with a bromo group attached to a branched alkyl chain
4. Compound with an amino group attached to a branched alkyl chain

[Four blank boxes to enter ranks]

#### b. \( S_N1 \) reactivity with \( HBr \)

Below are four organic compounds. You should rank their reactivity towards \( S_N1 \) mechanisms when reacted with hydrobromic acid (HBr).

From left to right:
1. Benzenol (phenol) with a hydroxyl group in the ortho position.
2. Cyclopentanol with an axial hydroxyl group on a ring carb.
3. Alkylbenzene with a methyl and a hydroxyl group on the same carbon (benzylic alcohol).
4. Branched compound with a hydroxyl group in the terminal position.

[Four blank boxes to enter ranks]

#### c. \( E2 \) reactivity with \( KO'Bu \)

Below are four organic compounds. You should rank their reactivity towards \( E2 \) mechanisms when reacted with potassium tert-butoxide (KO'Bu).

From left to right:
1. Alkyl halide with bromo substituent and a secondary carbon configuration.
2. Alkyl halide with bromo substituent and a linear alkyl chain.
3. Alkyl halide with bromo substituent in the middle of a linear alkyl chain.
4. Alkyl halide with bromo substituent in a linear alkyl chain.

[Four blank boxes to enter ranks]

#### d. Consider the following secondary halides. Changing the leaving group from fluoride to bromide would increase the rate of which of the following mechanisms? Circle all that apply.

**Compounds:**
1. A secondary halide with a fluorine substituent.
2. A secondary halide with a bromine substituent.

**Mechanisms to
Transcribed Image Text:# General Knowledge ### Rank the following compounds using numbers 1-4 in the box provided (1 = most, 4 = least) #### a. \( S_N2 \) reactivity with \( NaOMe \) Below are four organic compounds. You should rank their reactivity towards \( S_N2 \) mechanisms when reacted with sodium methoxide (NaOMe). From left to right: 1. Compound with a bromo group attached to a linear alkyl chain 2. Compound with an iodo group attached to a linear alkyl chain 3. Compound with a bromo group attached to a branched alkyl chain 4. Compound with an amino group attached to a branched alkyl chain [Four blank boxes to enter ranks] #### b. \( S_N1 \) reactivity with \( HBr \) Below are four organic compounds. You should rank their reactivity towards \( S_N1 \) mechanisms when reacted with hydrobromic acid (HBr). From left to right: 1. Benzenol (phenol) with a hydroxyl group in the ortho position. 2. Cyclopentanol with an axial hydroxyl group on a ring carb. 3. Alkylbenzene with a methyl and a hydroxyl group on the same carbon (benzylic alcohol). 4. Branched compound with a hydroxyl group in the terminal position. [Four blank boxes to enter ranks] #### c. \( E2 \) reactivity with \( KO'Bu \) Below are four organic compounds. You should rank their reactivity towards \( E2 \) mechanisms when reacted with potassium tert-butoxide (KO'Bu). From left to right: 1. Alkyl halide with bromo substituent and a secondary carbon configuration. 2. Alkyl halide with bromo substituent and a linear alkyl chain. 3. Alkyl halide with bromo substituent in the middle of a linear alkyl chain. 4. Alkyl halide with bromo substituent in a linear alkyl chain. [Four blank boxes to enter ranks] #### d. Consider the following secondary halides. Changing the leaving group from fluoride to bromide would increase the rate of which of the following mechanisms? Circle all that apply. **Compounds:** 1. A secondary halide with a fluorine substituent. 2. A secondary halide with a bromine substituent. **Mechanisms to
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