. What is the medical science concerned with the use of drugs in the treatment of disease? * a Pharmacotherapeutics b Pharmacology c Pharmacoepidemiology Pharmacognosy d Pharmacogenetics 2 Which of the following is ACCURATE about Reboxetine? * a MAO inhibitor b Noradrenaline reuptake inhibitor c Adrenergic agonist d Cholinergic agonist e Selective serotonin reuptake inhibitor 3 In Graded Dose-Response, which of the following parameters refers to the dose producing 50% of the maximum response? * a Potency b LD50 c Efficacy d Ceiling dose e ED50 4 Which of the following statements best describe a partial agonist? * a Interacts with more than one receptor
1. What is the medical science concerned with the use of drugs in the treatment of disease? *
a Pharmacotherapeutics
b Pharmacology
c Pharmacoepidemiology
Pharmacognosy
d Pharmacogenetics
2 Which of the following is ACCURATE about Reboxetine? *
a MAO inhibitor
b Noradrenaline reuptake inhibitor
c Adrenergic agonist
d Cholinergic agonist
e Selective serotonin reuptake inhibitor
3 In Graded Dose-Response, which of the following parameters refers to the dose producing 50% of the maximum response? *
a Potency
b LD50
c Efficacy
d Ceiling dose
e ED50
4 Which of the following statements best describe a partial agonist? *
a Interacts with more than one receptor type
b Blocks the effect of the antagonist
c Cannot produce the full effect even at high doses
d Has low potency but high efficacy.
e Has affinity but lacks efficacy
5 Which drug promotes transient muscle fasciculation followed by muscle paralysis that is not reversed by Neostigmine? *
a Hyoscyamine
b Rocuronium
c Succinylcholine
d Cisatracurium
e Pancuronium
6 Which of the following drugs is used in the diagnosis of myasthenia gravis? *
a Carbachol
b Neostigmine
c Edrophonium
d Suxamethonium
e Pyridostigmine
7 Which theory in quantifying drug-receptor interaction states that maximum pharmacologic effect is obtained if and when all receptors are occupied? *
a Hypothesis of Clark
b Rate Theory
c Hypothesis of Paton
d Lock and Key Hypothesis
e Hypothesis of Ariens and Stephenson
8 Complete the statement: On metabotropic receptors, Gq protein activation results in the action of the enzyme _____________, splitting _________ into ________ and ________ resulting to smooth muscle contraction. *
a Phospholipase C, PIP2, IP3, DAG
b Phospholipase C, IP3 DAG, PIP2
c Phospholipase A2, PIP2, IP3, DAG
d Phospholipase C, IP3, PIP2, DAG
e Phospholipase A2, DAG, PIP2, IP3
9 Which anticholinergic agent is used in the management of asthma exacerbations? *
a. Ipratropium
b. Biperiden
c. Dicycloverine
d. Trospium
e. Cyclopentolate
10 Which of the following is termed as an acetylcholinesterase regenerator? *
a. Edrophonium
b. Pralidoxime
c. Ecothiophate
d. Neostigmine
e. Atropine
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