Extraction Post Lab (2)

Multistep synthesis of Lidocaine Lab 1) How many grams of starting material do you need? It is given in moles below but how many grams? 2) How to calculate theoretical yield? Part One Method A. Preparation of alpha-Chloro-2,6-dimethylacetanilideCombine 0.033 mol of 2,6-dimethylaniline with 25 mL of glacial acetic acid (or ethyl acetateor THF) and 0.033 mol of alpha-chloroacetyl chloride, in that order, in an appropriately sized Erlenmeyer flask. With the aid of a hot water bath, warm the solution to 40-50°C, remove the flask from the bath, and add a solution of 5 g of sodium acetate trihydrate dissolved in 100 mL of water.

Benzyl alcohol and methyl benzoate (shown below) are dissolved in an ether solution. Choose the best process to separate the following two compounds using an acid-base extraction. 28 benzyl alcohol methyl benzoate A) Add aqueous NaOH and extract the benzyl alcohol into the aqueous layer. B) Add aqueous NaHCO3 and extract the benzyl alcohol into the aqueous layer. C) Add aqueous NaOH and extract the methyl benzoate into the aqueous layer. 3 D) Add aqueous HCI and extract the benzyl alcohol into the aqueous layer. E) These two compounds cannot be separated using an acid-base extraction.

Name this compound:

A fellow student somehow mixed an aspirin sample with paracetamol after synthesising both. Explain how you would separate aspirin from paracetamol using liquid-liquid extraction.

Show how you would use extractions with a separatory funnel to separate a mixture of the following compounds: benzoicacid, phenol, benzyl alcohol, aniline

Explain the purpose of the Qualitative Tests for carbonyls and Unknown carbonyl.

1. Create a flowchart for the synthesis and purification of phenacetin. Draw out your steps for the extraction process and label the organic and aqueous layers in your diagrams. Indicate where the product is in each step. 2. Draw the mechanism for the deprotonation of the phenol group of acetaminophen by potassium carbonate. Label the acid, base, conjugate acid and conjugate base. How do you know potassium carbonate is a strong enough base to do this deprotonation?

A mixture of compounds is dissolved in ether, and extracted with 10% NaHCO3 solution. The aqueous extract is treated with 6M HCI solution, and extracted with dichloromethane. If the mixture contains an amine, where is it? The bottom layer of the first extraction O The top layer of the second extraction The top layer of the first extraction The bottom layer of the second extraction

Consider the following possible compounds Compound Benzophenone Naphthalene Cinnamic acid Aspirin 3-Chlorobenzoic acid Sulfanilamide MP (°C) 48-49 79-80 133 136 154 165-166 1. A solid melts is found to melt at the range 153-161 °C. What could it be? a. Pure aspirin b. Pure 3-chlorobenzoic acid c. Pure sulfanilamide d. Impure aspirin e. Impure 3-chlorobenzoic acid f. Impure sulfanilamide

20. Which of the following statements is false?       Positive result for an aldehyde is indicated by an orange to red precipitate using Tollen’s reagent.       Both the 2nd & 3rd statements only.       Positive result for an aldehyde is indicated by a greenish precipitate using 2,4-DNPH reagent.       Positive result for a ketone is indicated by a red-orange precipitate using chromic acid test.       All of the above

Why do we react β-naphthol with ethyl iodide rather than react ethyl alcohol with 2-Iodo naphthalene? Draw out a putative mechanism for ethyl alcohol reactingwith 2- Iodo naphthalene and explain why this method wouldn’t work. in Synthesis of Nerolin experemint

When doing an acid-base extraction, why would one use sodium hydroxide rather than sodium bicarbonate to deprotonate acetylsalicyclic acid to make a salt?

1. Using a Merck Index, identify the physiological effects of: Methyl Salicylate - Octyl Acetate - Benzyl Acetate - Ethyl Butyrate -

5. The pKas of chemicals HX and HY are 5.0 and 7.0 respectively. The pKa of carbonic acid H,CO, 3. is 6.0. If you made up an ether solution of chemicals HX and HY in a separatory funnel, and then added an aqueous solution of sodium bicarbonate NaHCO3 to that separatory funnel, would both HX and HY stay in the ether layer? Or would either or both of them transfer into the aqueous layer? If one goes into the water layer, will it be in its neutral HX/HY form, or in it's deprotonated anionic form? ilter HX: ether layer or water layer? If in the water layer, in HX or X- form? Explain HY: ether layer or water layer? Explain.

You started with 84g of aniline and 28 ml of acetic anhydride. Give % yield of acetanilide. 653 AM 10/22/2021 B 62PF A D)

You have learned that ester may be hydrolyzed in aqueous base. Why does a workup using 50ml of 10% NaOH and 50g of ice not hydrolyze a nitro benzocaine derivative?

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