311-midterm-2014-practice-mt

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Studocu is not sponsored or endorsed by any college or university 311 Midterm 2014 - Practice MT Biol (University of Calgary) Studocu is not sponsored or endorsed by any college or university 311 Midterm 2014 - Practice MT Biol (University of Calgary) Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

Biology 311 Midterm Exam- Fall 2014 Page 1 of 11 Name:_________________ Lab Section:_________ T.A. Name:_________ Biology 311 Midterm Exam Fall 2014 Time: 2hrs The use of wireless access devices such as cell phones, computers, etc. during examination will not be allowed. Calculators are allowed in the exam; however, they must NOT be programmable. The total number of marks for each question is given at the beginning of each question. The distribution for each part of the question is in parentheses at the end of each part. Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

Biology 311 Midterm Exam- Fall 2014 Page 2 of 11 Question 1 —8 marks A ‘liger’ is a lion and tiger mixed. Ligers are bred for their skills in magic. Two alleles of one gene determine the coat colour of the liger. They can either have brown (B) or gold (G) coat colour. Two alleles of a separate, independent gene determine the strength of their magic. They can either have high magic (H) or low magic (L). Assume that Ligers are fully fertile and give a large number of offspring when mated. The results for five matings of Liger phenotypes are as follows. Mating Parental Phenotypes Number of progeny B, H B, L G, H G, L Parent 1 Parent 2 1 B,H G,H 321 101 310 107 2 B,H B,L 219 207 64 71 3 B,H G,H 722 231 0 0 4 B,H G,L 404 0 387 0 5 B,L G,H 70 91 86 77 a) Which phenotypes (B or G and H or L) are dominant? (2 marks) b) Using the symbols ‘A’ and ‘a’ for coat colour and “B’ and ‘b’ for magic, what were the genotypes of the parents in each of the following matings? (6 marks) Mating Parental Genotype (Parent 1) Parental Genotype (Parent 2) 1 3 5 Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

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Biology 311 Midterm Exam- Fall 2014 Page 3 of 11 Question 2 —10 marks Drosophila females of wild-type appearance, but heterozygous for three autosomal genes, are mated with males showing three autosomal recessive traits: glassy eyes , coal- coloured bodies , and striped thoraxes . One thousand (1000) progeny of this cross are collected and all fall into one of the six following phenotypic classes. Phenotype Number Part ‘d’ Wild type 27 Striped thorax 11 Coal Body 484 Glassy eyes, coal body 8 Glassy eyes, striped thorax 441 Glassy eyes, coal body, striped thorax 29 Use the following symbols – Glassy eyes ( G -dominant, g -recessive), Coal-coloured bodies ( B -dominant, b -recessive) and Striped thoraxes ( T -dominant, t recessive). a) What were the genotypes of the pure breeding parents (P0) of the Drosophila females? (2) b) Calculate the map distance between each gene pair and draw a linkage map. (4) c) What are the phenotypes of the two double cross-over classes? (2) d) Normal-appearing heterozygous males, which would have been produced from mating the two P0 pure breeding parents, were mated with females showing glassy eyes , coal-coloured bodies , and striped thoraxes . Of 1000 progeny produced, indicate the numbers of the various phenotypic classes you would expect. Write your answers in the third column on the table above. (Remember that there is no crossing over in Drosophila males). (2) Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

Biology 311 Midterm Exam- Fall 2014 Page 4 of 11 Question 3 —10 marks Four homozygous recessive mutant lines of Drosophila melanogaster (labeled 1 through 4) showed abnormal leg coordination, which made their walking highly erratic. These lines were intercrossed; the phenotypes of the F1 flies are shown in the following grid, in which ‘+’ represents wild-type walking and ‘-‘ represents abnormal walking. 1 2 3 4 1 - + + + 2 + - - + 3 + - - + 4 + + + - a) What type of test does this represent? (2 marks) b) How many different genes were mutated in creating these four lines? (2 marks) c) Using symbols ‘A’ and ‘a’ for dominant and recessive alleles respectively, and sequential letters as needed for other genes (e.g. b, c, etc), write out the complete genotypes for all four lines. (2 marks) d) Using these same symbols, write the complete genotype of the F1 fly generated when line 1 and line 2 are crossed (2 marks). e) Do these data tell us the total number of genes taking part in leg coordination (Yes or No)? In one SHORT sentence or statement, why or why not? (2 marks) Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

Biology 311 Midterm Exam- Fall 2014 Page 5 of 11 Question 4 —6 marks ‘A’ and ‘B’ genes are located on the same autosomal chromosome in Drosophila . Gene ‘D’ is located on another autosome. a) An AB/ab; D/d female fly was crossed with a male tester. If ‘A’ and ‘B’ genes are 30 map units apart, what proportion of progeny would you expect to be ab/ab; d/d? (3 marks) b) An AB/ab; D/d female fly was crossed with a male fly of the same genotype. If ‘A’ and ‘B’ genes are 70 map units apart, what proportion of progeny would you expect to be ab/ab; d/d? (remember that there is no crossing over in Drosophila males) (3 marks) Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

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Biology 311 Midterm Exam- Fall 2014 Page 6 of 11 Question 5 —14 marks Joe is colour blind (rare condition). Both his mother and his father have normal vision, but his mother’s father (Joe’s maternal grandfather) is colour blind. All Joe’s other grandparents have normal colour vision. Joe has three sisters- Patty, Betsy and Lora- all with normal colour vision. Joe’s oldest sister, Patty, is married to a man with normal colour vision; they have two children, a 9-year old colour-blind boy and a 4-year old girl with normal colour vision. a) Using standard symbols and labels, draw a pedigree of Joe’s family with respect to colour blindness. (4 marks) b) What is the most likely mode of inheritance for colour blindness in Joe’s family? (2 marks) c) If Joe marries a woman who has no family history of colour blindness, what is the probability that their first child will be a colour-blind boy? (2 marks) Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

Biology 311 Midterm Exam- Fall 2014 Page 7 of 11 d) If Joe marries a woman who is a carrier of the colour-blind allele, what is the probability that their first child will be colour-blind? (2 marks) e) If Patty and her husband have another child, what is the probability that the child will be a colour-blind boy? (2 marks) f) If Betsy marries a man with no family history of colour blindness, what is the probability that their first child will be a colour-blind boy? (2 marks) Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

Biology 311 Midterm Exam- Fall 2014 Page 8 of 11 Question 6—9 marks In a generalized-transduction experiment, phages are collected from an E. coli donor strain of genotype cys+ leu+ thr+ and used to transduce a recipient of genotype cys- leu- thr- . Initially, the treated recipient population is plated on a minimal medium supplemented with leucine and threonine. Many colonies are obtained. a) List all possible genotypes of these colonies with respect to the three genes. (2) b) The colonies are then tested to see if they can grow on three different types of media: (1) minimal plus threonine only (2) minimal plus leucine only, and (3) minimal. For each of these media, what genotypes could, in theory, grow on that media. (3) Media Genotype(s) 1 2 3 c) Of the original colonies, 56% are observed to grow on medium 1, 5% on medium 2, and no colonies on medium 3. What are the actual genotypes of the colonies that grew on media 1 and 2. (2) Media Genotype(s) 1 2 d) Draw a map showing the order of the three genes and that indicates which of the two outer genes is closer to the middle gene. (2) Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

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Biology 311 Midterm Exam- Fall 2014 Page 9 of 11 Question 7 —7 marks a) A fly is isolated that has a relatively large inversion in one of their chromosomes. This chromosome can be written as 123765489, with each number representing a region on the chromosome, and the centromere is between regions 1 and 2. A normal chromosome would be written as 123456789, again with the centromere between regions 1 and 2. If this fly has one chromosome with the inversion, and its homologue is normal, draw how these chromosomes would pair during metaphase of meiosis I, including numbers 1 through 9 for each chromosome (be sure to draw all of the chromatids) (4 marks) b) It is known that in normal flies, a gene in region 2 is 30 map units from a gene in region 9. If someone were to determine the distance between these two genes in flies with the following chromosomal make-up, would you expect the observed genetic distance to be 1) ~ 30 map units 2) much greater than 30 map units 3) much smaller than 30 map units? (Write 1, 2 or 3 for each of the following situations) (3 marks) i) two normal chromosomes ii) one normal chromosome, one inverted chromosome iii) two inverted chromosomes. Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

Biology 311 Midterm Exam- Fall 2014 Page 10 of 11 Question 8 —8 marks In a certain diploid plant, the three loci A, B and C are linked as follows You are provided with a plant with the genotype Abc/aBC a) Draw how these chromosomes would appear in Metaphase of Meiosis I, including the appropriate number of chromatids, and with the centromere to the left of A . (2 marks) b) List all possible genotypes of gametes that this plant will form, and in what proportions. (4 marks) Genotypes Proportion c) If the plant is selfed, what proportion of the progeny will be of the genotype abc/abc ? (2 marks) Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

Biology 311 Midterm Exam- Fall 2014 Page 11 of 11 Question Number Total Possible Mark Obtained 1 6 2 10 3 10 4 6 5 14 6 9 7 7 8 8 Total 70 Downloaded by Frkn Dym (frkndym28@gmail.com) lOMoARcPSD|16709386

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